Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3329 - 3336 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7902 | [D-Trp8]-γ-MSH |
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Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
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| BCC7903 | ERB 041 |
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Potent ER<span class='symbol'>β</span> agonist; displays >200-fold selectivity for ER<span class='symbol'>β</span> over ER<span class='symbol'>α</span> (IC<sub>50</sub> values are 5 and 1216 nM for human ER<span class='symbol'>β</span> and ER<span class='symbol'>α</span>; 3.1 and 620 nM for rat ER<span class='symbol'>β</span> and ER<span class='symbol'>α</span>; and 3.7 and 750 nM for mouse ER<span class='symbol'>β</span> and ER<span class='symbol'>α</span> respectively).
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| BCC7904 | PF 4800567 hydrochloride |
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Selective casein kinase 1<span class='symbol'>ε</span> inhibitor; displays 22-fold greater potency towards CK1<span class='symbol'>ε</span> than CK1<span class='symbol'>δ</span> (IC<sub>50</sub> values are 32 and 711 nM for CK1<span class='symbol'>ε</span> and CK1<span class='symbol'>δ</span> respectively). ATP competitive. Displays minimal effect on the circadian clock.
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| BCC7905 | RP 001 hydrochloride |
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Potent agonist of S1P1 receptors (EC50 = 9 pM). Induces internalization and polyubiquitination of S1P1 in vitro. Selective for S1P1 over S1P2 - S1P4.
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| BCC7906 | Methyl 5-{2-[(tert-butylamino)carbothioyl]carbohydrazonoyl}-1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate |
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Competitive, reversible antagonist of the orphan receptor GPR35 (K<sub>i</sub> = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and <span class='symbol'>β</span>-arrestin recruitment induced by pamoic acid.
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| BCC7907 | VU 0357017 hydrochloride |
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Positive allosteric modulator of muscarinic M<sub>1</sub> receptors (EC<sub>50</sub> = 198 nM). Displays no activity at M<sub>2</sub>-M<sub>5</sub> at concentrations up to 30 <span class='symbol'>μ</span>M. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.
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| BCC7908 | SMER 28 |
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Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T <span class='symbol'>α</span>-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.
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| BCC7909 | Pamoic acid disodium salt |
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GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC<sub>50</sub> values are 22 and 65 nM respectively). Mediates recruitment of <span class='symbol'>β</span>-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.
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