Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5212 | 3,4,5-Trimethoxycinnamyl alcohol |
| 1. 3,4,5-Trimethoxycinnamyl alcohol shows significant antimicrobial and cytotoxic activities. | |
| BCN5213 | Pandamarilactonine A |
| 1. Pandamarilactonine A has antimicrobial activity, it is active with an MIC of 15.6 ug/mL and MBC of 31.25 ug/mL against Pseudomonas aeruginosa. | |
| BCN5216 | Centrolobol |
| 1. (-)-Centrolobol has antifibrotic activity, it can significantly inhibit the proliferation of HSC-T6 cells in a dose-dependent manner. 2. Centrolobol exhibits strong cytotoxic activity against KB cell line. | |
| BCN5217 | Corydalmine |
| 1. Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. 2. 1-Corydalmine significantly inhibits spore germination of all the fungi at 100 to 1500 ppm. 3. l-Corydalmine exhibits potent analgesic activity in preclinical models, it is under development as an oral analgesic agent. | |
| BCN5218 | Harmaline |
| Harmaline is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase. Harmaline has antileishmanial, bioinsecticidal, and vasorelaxant effects. It has antagonist effects on alpha1-adrenorecepteors in non-competitive manner, it also exerts an antioxidant activity by scavenging the free radical generated by DPPH.Harmaline may prevent dopamine-induced mitochondrial damage and PC12 cell death through a scavenging action on reactive oxygen species and inhibition of monoamine oxidase and thiol oxidation. | |
| BCN5221 | 5'-Demethylaquillochin |
| 1. 5'-Demethylaquillochin exhibits the most potential chemopreventive ability. 2. 5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes. | |
| BCN5224 | Magnolin |
| Magnolin has anti-inflammatory, anti-histaminic, and antioxidative effects, it might be a naturally occurring chemoprevention and therapeutic agent capable of inhibiting cell proliferation and transformation by targeting ERK1 and ERK2. Magnolin can ameliorate the renal tubular necrosis, apoptosis, and the deterioration of renal function, it reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. | |
| BCN5226 | Sideroxylin |
| 1. Sideroxylin can synergistically enhance the antimicrobial activity of the alkaloid berberine (also a constituent of H. canadensis) against Staphylococcus aureus by inhibition of the NorA multidrug resistance pump. | |
