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Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN5175	Rediocide A
1. Rediocide A, an insecticide, can inhibit calcium mobilization in Drosophila G-protein- coupled receptors (GPCR)s other than methuselah, it can induce GPCR desensitization and internalization, and such effects are mediated by the activation of conventional protein kinase C. 2. Rediocide A possesses potent activity against fleas (Ctenocephalides felis) in an artificial membrane feeding system and exhibited LD(90) values ranging from 0.25 to 0.5 ppm.
BCN5176	Dihydrodehydrodiconiferyl alcohol
1. Dihydrodehydrodiconiferyl alcohol may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis. 2. Dihydrodehydrodiconiferyl alcohol exhibits in vitro cytotoxicity in various cancer cell lines.
BCN5178	Reynosin
1. Reynosin has hepatoprotective effects, it can inhibit thioacetamide-induced apoptosis in primary hepatocytes and an in vivo mouse model. 2. Reynosin has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α-synuclein protein expression. 3. Reynosin exhibits a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM. 4. Reynosin has strong anti-mycobactericidal activity, with a minimal bactericidal concentration (MBC) of 128ug/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains and a minimal inhibitory concentration (MIC) of 64, 64, 128, 128 and 128ug/mL against the H37Rv, 104-2010, 63-2009, 366-2009 and 430-2010 Mtb strains, respectively. 5. Reynosin can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophages. 6. Reynosin shows cytotoxicity against the KB cancer cell line (ATCC CCL17), with IC50 value of 2.7 microg/mL. 7. Reynosin shows moderate anti-inflammatory activity, it exhibits a concentration-related decrease in the levels of IL-1β, IL-6, TNF-α, PGE2, lipoxgenase-5, and COX-2.
BCN5179	11beta-Hydroxycedrelone
1. 11β-Hydroxycedrelone has cytotoxic activity, it exhibits moderate inhibitory activity against HL-60 cell line with the IC50 values of 8.9 uM.
BCN5180	Tomentin
1. Tomentin has anti-inflammatory effects, it can inhibit the formation of λ-carrageenan footpad edema at 58%.
BCN5181	7-Geranyloxy-6-methoxycoumarin
1. 7-Geranyloxy-6-methoxycoumarin shows significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1).
BCN5182	Docosyl caffeate
1. Docosyl caffeate exhibits potent elastase inhibitory activity, with the IC50 value of 1.4 microg/mL . 2. Docosyl caffeate shows moderate antioxidant activity in DPPH and ABTS scavenging assays. 3. Docosyl caffeate has significant anti-inflammation activity in mice with ear swelling.
BCN5184	Erythristemine
1. (+)-Erythristemine shows moderate toxicity to brine shrimp (LC50 23 ppm) and moderate (IC50=86microg/ml) radical scavenging properties against stable 2,2-diphenyl-1-picrylhy--drazyl (DPPH) radical.