Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5095 | Epitulipinolide |
| 1. Epitulipinolide has antitumor activity. 2. Epitulipinolide diepoxide has antioxidative activity and chemopreventive activity in skin melanoma cells, it can significantly inhibit the proliferation of melanoma cells. | |
| BCN5097 | Thalictrimine |
| 1. Allocryptopine and protopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. 2. Allocryptopine induces a relaxing effect on the ileum by inhibiting phosphodiesterase enzyme, and thus elevating cellular cAMP and its contractile effect on the urinary bladder by affecting alpha-adrenergic receptors in this tissue. 3. Allocryptopine and benzyltetrahydropalmatine can block human ether-a-go-go related gene (hERG) potassium channels expressed in HEK293 cells. 4. Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis. | |
| BCN5101 | Celaphanol A |
| 1. Celaphanol A shows moderate inhibition in both NF-κB activation and nitric oxide production, suggests that it is a possible inhibitor of the NF-kappaB pathway and has antiinflammatory activity. | |
| BCN5102 | Sanguinarine |
| Sanguinarine possesses anticancer, antimicrobial, anti-inflammatory, and antioxidant properties, it has therapeutic potential in preventing the neurodegenerative diseases, it may be used to develop a potential therapeutic drug for treating cardiac remodeling and heart failure and shows protective effects on teeth and alveolar bone health. Sanguinarine can inhibit osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-κB and ERK signaling pathways, and can protect against cardiac hypertrophy and fibrosis via inhibiting NF-κB activation. | |
| BCN5103 | Bryonolic acid |
| 1. Bryonolic acid has anti-allergic activity. 2. Bryonolic acid exhibits cytotoxic activity to various tumor cells in vitro, independent of cell type. 3. Bryonolic acid can induce a marked increase in the expression of a phase 2 response enzyme, heme oxygenase 1 (HO-1), in a dose-dependent manner. 4. Bryonolic acid can protect PC12 cells against NMDA-induced apoptosis by inhibiting Ca2+ influx and regulating gene expression in the Ca2+-CaMKII-CREB signal pathway, supports that it may be a promising neuroprotective agent for the treatment of cerebral ischemia disease. 5. Bryonolic acid has anti-inflammatory and antioxidant activities, it can reduce the inflammatory mediator NO by suppressing the expression of the inflammatory enzyme inducible nitric oxide synthase (iNOS) in LPS-activated RAW 264.7 macrophage cells. | |
| BCN5104 | Geniposide |
| Geniposide exhibits anti-diabetic, antidepressant-like, antioxidative, anti-apoptotic, antiproliferative and neuroprotective activities. Geniposide is an agonist for GLP-1 receptor, it regulates expression of anti-oxidative proteins including HO-1 and Bcl-2 by activating the transcriptor of p90RSK via MAPK signaling pathway in PC12 cells. Geniposide may suppress TGF-β1-induced EMT in hepatic fibrosis by inhibiting the TGFβ/Smad and ERK-mitogen-activated protein kinase (MAPK) signaling pathways. | |
| BCN5105 | Monomethyl kolavate |
| 1. Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM. | |
| BCN5108 | 5'-S-Methyl-5'-thioadenosine |
| 1. S-Methyl-5′-thioadenosine can inhibit the activity of ThiC (4-amino-5-hydroxymethyl-2- methylpyrimidine phosphate synthase). | |
