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Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN5257	Quercetin 3,4'-dimethyl ether
1. Quercetin 3,4’-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM). 2. 5,7,3'-Trihydroxy-3,4'-dimethoxyflavone (Quercetin 3,4’-dimethyl ether ) has high cytotoxic against leukemia cells, it induces cell death is mediated by an intrinsic dependent apoptotic event involving mitochondria and MAPKs, and through a mechanism independent of the generation of reactive oxygen species, suggests that it could be useful in the development of novel anticancer agents. 3. Quercetin 3,4’-dimethyl ether shows anti-inflammatory activity.
BCN5258	Myricanol
1. Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells. 2. Myricanol can significantly decelerate tumor growth in vivo by inducing apoptosis.
BCN5259	Hypophyllanthin
1. Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. 2. Hypophyllanthin can modulate the vascular tension via the endothelium-independent mechanisms. 3. Hypophyllanthin can directly inhibit P-gp activity and does not interfere with MRP2 activity, it may reversibly inhibit P-gp function. 4. Hypophyllanthin offers a promising means for treatment of chronic muscle pain. 5. Hypophyllanthin has estrogenic properties against carbofuran induced toxicity in female rats.
BCN5261	Pachypodol
1. Pachypodol has cytotoxic potential ,can inhibit the growth of CaCo 2 colon cancer cell line in vitro. 2. Pachypodol has antibacterial and antifungal activities against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata. 3. Pachypodol exhibits anti-emetic effects. 4. Pachypodol inhibits the water-splitting enzyme activity.
BCN5262	Abieta-8,11,13-triene-7,15,18-triol
1. Abieta-8,11,13-triene-7alpha,15,18-triol,7alpha,8alpha,13beta,14beta-diepoxyabietan-18-oic acid, and 18-nor-abieta-8,11,13-triene-4alpha,7alpha,15-triol may have inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), they may as a primary screening for antitumor promotors.
BCN5265	7-Oxodehydroabietinol
1. 7-Oxodehydroabietinol shows moderate cytotoxicity against a human lung carcinoma cell line. 2. 7-Oxodehydroabietinol exhibits significant antibacterial activity against gram (±) bacteria.
BCN1454	2-2'-(Hydroxytetracosanoylamino)-octadecane-1,3,4-triol tetraacetate
1. (2S,3S,4R,2′R )-2-(2′-Hydroxytetracosanoylamino) octadecane-1,3,4-triol at concentration of 100 ug/mL shows selectively inhibitory activity against phospholipase A 2 (PLA 2) secreted from Crotalus adamenteus venom, but inactive against PLA 2 of bee venom (Apis mellifcra).
BCN5266	Alpinumisoflavone
1. Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation. 2. Alpinumisoflavone is endowed with estrogenic properties accounting, at least in part, for E. lysistemon effects. 3. Alpinumisoflavone induces cell death, may be via repressing both the ERK/MAPK and NF-κB pathways. 4. Alpinumisoflavone, abyssione-V 4'-O-methyl ether, 6,8-diprenylgenistein, and burttinone are active against both Gram-negative and Gram-positive bacteria, the minimum inhibitory concentration values obtained (MIC) ranged from 3.9 ug/mL to 125 ug/mL.