Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3369 - 3376 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7942 | DIDS |
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ClC-Ka chloride channel blocker (IC<sub>50</sub> = 100 <span class='symbol'>μ</span>M). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC<sub>50</sub> = 4.88 <span class='symbol'>μ</span>M in rat DRG neurons). Inhibits RAD51 recombinase activity (K<sub>D</sub> = 2 <span class='symbol'>μ</span>M).
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| BCC7943 | ONO 2506 |
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Inhibits S-100<span class='symbol'>β</span> synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.
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| BCC7944 | NCX 4040 |
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NO-donating aspirin; anti-inflammatory. Blocks inflammatory mediator production in isolated human monocytes (IC<sub>50</sub> values are 0.07, 0.13, 0.15 and 0.18 <span class='symbol'>μ</span>M for IL-1<span class='symbol'>β</span>, PGE<sub>2</sub>, IL-10 and TNF-<span class='symbol'>α</span> respectively). Decreases COX-2 expression (IC<sub>50</sub> = 0.13 <span class='symbol'>μ</span>M); disrupts proteasome-mediated degradation of i<span class='symbol'>κ</span>B-<span class='symbol'>α</span>. Antiproliferative in HCT116 colon cancer cells; sensitizes drug-resistant ovarian tumor cells to cisplatin.
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| BCC7945 | Phalloidin |
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Promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.
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| BCC7946 | (R)-(+)-Etomoxir sodium salt |
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Inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits <span class='symbol'>β</span>-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.
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| BCC7947 | (+)-Fluprostenol |
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Prostaglandin F2α (FP) receptor agonist (Ki = 49.9 nM; EC50 = 2.4 nM). Stimulates intracellular calcium mobilization in cloned human ocular FP receptors, rat A7r5 cells and mouse 3T3 cells (EC50 values are 17.5, 19.1 and 37.3 nM respectively). Analog of prostaglandin F2α. Isopropyl ester travaprost (Cat. No. 4218) also available.
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| BCC7948 | GTS 21 dihydrochloride |
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Partial agonist of <span class='symbol'>α</span>7 nicotinic acetylcholine receptors (nAChRs); also a weak <span class='symbol'>α</span>4<span class='symbol'>β</span>2 and 5-HT<sub>3</sub> antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation.
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| BCC7949 | PS 1145 dihydrochloride |
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Selective I<span class='symbol'>κ</span>B kinase (IKK) inhibitor (IC<sub>50</sub> = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits I<span class='symbol'>κ</span>B-<span class='symbol'>α</span> phosphorylation and NF<span class='symbol'>κ</span>B activation in HeLa cells. Inhibits NF<span class='symbol'>κ</span>B-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-<span class='symbol'>α</span>-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-<span class='symbol'>α</span> production <em>in vivo</em>. Orally active.
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