Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3353 - 3360 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7926 | TC-SP 14 |
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Potent and selective S1P<sub>1</sub> agonist (EC<sub>50</sub> values are 0.042 and 3.47 <span class='symbol'>μ</span>M for human S1P<sub>1</sub> and S1P<sub>3</sub> respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.
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| BCC7927 | Psora 4 |
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Potent K<sub>V</sub>1.3 channel blocker (EC<sub>50</sub> = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818. Displays 17- to 70-fold selectivity over closely-related K<sub>V</sub>1 channels (K<sub>V</sub>1, K<sub>V</sub>2, K<sub>V</sub>4 and K<sub>V</sub>7); exhibits activity at K<sub>V</sub>1.5 (IC<sub>50</sub> = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC<sub>50</sub> values are 25 and 60 nM respectively).
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| BCC7928 | BIMU 8 |
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Potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.
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| BCC7929 | DLPC |
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Selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro. Induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose. Exhibits antidiabetic effects.
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| BCC7930 | (S)-(+)-Ketamine hydrochloride |
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NMDA receptor antagonist. Displays neuroprotective efficacy <em>in vitro</em>. Racemate also available.
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| BCC7931 | Calhex 231 hydrochloride |
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Negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [<sup>3</sup>H]inositol phosphate levels elicited by wild-type hCasR activation (IC<sub>50</sub>= 0.39 <span class='symbol'>μ</span>M in transiently transfected HEK293 cells).
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| BCC7932 | BAY 41-2272 |
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Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC <span class='symbol'>α</span><sub>1</sub> subunit. Inhibits platelet aggregation (IC<sub>50</sub> = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC<sub>50</sub> = 0.30 <span class='symbol'>μ</span>M). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.
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| BCC7933 | A 1070722 |
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Potent glycogen synthase kinase-3 (GSK-3) inhibitor (K<sub>i</sub> = 0.6 nM for GSK-3<span class='symbol'>α</span> and GSK-3<span class='symbol'>β</span>). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau <em>in vitro</em>; protects rat primary cortical neurons against <span class='symbol'>β</span> amyloid and glutamate challenge. Brain penetrant.
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