Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3409 - 3416 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7983 | MA 2029 |
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Potent and selective, competitive motilin receptor antagonist (IC50 = 4.9 nM). Selective for the motilin receptor over a range of other receptors and ion channels. Inhibits motilin-induced duodenal muscle contractions in vitro. Also inhibits motilin-induced colonic and abdominal contractions in vivo. Orally active.
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| BCC7984 | MaxiPost |
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Potassium channel modulator. Acts as a positive modulator at neuronal K<sub>v</sub>7 channels and calcium-activated K<sup>+</sup> channels (BK<sub>Ca</sub>) in HEK293 cells. Displays negative modulatory activity at K<sub>v</sub>7.1 channels (K<sub>i</sub> = 3.7 <span class='symbol'>μ</span>M) and GABA<sub>A</sub> receptors. Displays anxiolytic activity <em> in vivo</em>.
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| BCC7985 | LY 2389575 hydrochloride |
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Selective negative allosteric modulator of mGlu<sub>3</sub> (IC<sub>50</sub> = 190 nM). Exhibits > 65-fold selectivity for mGlu<sub>3</sub> over other mGlu receptors. Abolishes the neuroprotective action of LY 379268</a> against amyloid <span class='symbol'>β</span> toxicity in mixed cortical neuronal and astrocyte cell cultures.
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| BCC7986 | Methylmalonate |
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Intracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.
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| BCC7987 | Ethacrynic acid - d5 |
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Deuterated ethacrynic acid. Used as an internal standard for GC- or LC-mass spectrometry.
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| BCC7988 | NSC 624206 |
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Ubiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.
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| BCC7989 | 9-Phenanthrol |
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Selective TRPM4 blocker (IC<sub>50</sub> = 20 <span class='symbol'>μ</span>M in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
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| BCC7990 | DR 4485 hydrochloride |
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High affinity and selective 5-HT7 antagonist (pKi = 8.14). Exhibits selectivity for 5-HT7 over other 5-HT receptors. Inhibits 5-HT-induced cAMP accumulation in HEK-293 cells expressing the 5-HT7 receptor. Orally bioavailable.
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