Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5451 | Epitulipinolide diepoxide |
| 1. Epitulipinolide diepoxide has antioxidative and chemopreventive activities in skin melanoma cells, can significantly inhibit the proliferation of melanoma cells. 2. Epitulipinolide diepoxide possessea cytotoxic activity against KB cells. | |
| BCN5452 | Methyllinderone |
| 1. Methyllinderone has antioxidant property. 2. Methyllinderone is a human chymase inhibitor. 3. Methyllinderone shows moderate to weak antifungal activities against various pathogenic fungi. 4. Methyllinderone can inhibit farnesyl protein transferase with IC50 value of 55.3+/-4.1microM and selectively inhibit the growth of H-ras-transformed rat-2 cell lines with a GI50 value of 0.3 microM. 5. Methyllinderone shows significant cytotoxicity against mouse melanoma (B16-F10), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with ED(50) values of 2.2, 2.5, 8.3 mug/ml, respectively. | |
| BCN5455 | Pinusolidic acid |
| 1. Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml). | |
| BCN5456 | Yatein |
| 1. Yatein is a lignan precursor of podophyllotoxin, a key agent in anticancer drugs. 2. Yatein can significantly suppress HSV-1 multiplication in HeLa cells without apparent cytotoxicity. | |
| BCN5459 | Nerolidol |
| Nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs. Nerolidol shows anti-cancer, sedative, antiulcer, antifungal, and antifeeding effects. Nerolidol can inhibit the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concentrations of 85, 74, 75, and 67 uM, respectively. | |
| BCN5461 | Sinoacutine |
| 1. Sinoacutine has protective effects against hydrogen peroxide-induced cell injury. | |
| BCN5462 | Medioresinol |
| 1. Medioresinol possesses a lesishmanicidal activity and cardiovascular disease risk reduction. 2.(+)-Medioresinol has anti-bacterial, antifungal and anti-biofilm activities. 3. Medioresinol has antioxidative activity. 4. Medioresinol has antiamyloidogenic activity via reduction in the amount of β-secretase, it is a potentially valuable antiamyloidogenic agent for the prevention and treatment of Alzheimer disease. | |
| BCN5463 | Lipiferolide |
| 1. Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells. 2. Liriodenine has antiplasmodial activity. 3. Lipiferolide and epitulipinolide diepoxide possess cytotoxic activity against KB cells. | |
