Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5486 | 3-O-Acetyloleanolic acid |
| 3-O-Acetyloleanolic acid exhibits anti-angiogenic effects, it inhibits proliferation, migration and tube formation of umbilical vein endothelial cells (HUVECs) in a dose-dependent manner; it can inhibit VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral squamous cell carcinoma animal model. 3-O-Acetyloleanolic acid has antihyperglycemic activity, it shows a significant decrease in the glucose level of STZ-induced diabetic rats. | |
| BCN5487 | Crategolic acid |
| Crategolic acid(Maslinic acid) has neuroprotective, anti-inflammatory, anti- osteoporosis, cytotoxic and antiviral activities, it suppresses RANKL-induced osteoclastogenesis through NF-κB and MAPK/AP-1 signaling pathways , and has beneficial effects on hypoxic neurons by suppressing iNOS activation.Crategolic acid as a feed additive to stimulate growth and hepatic protein-turnover rates in rainbow trout ( Onchorhynchus mykiss ). | |
| BCN5488 | Genkwanin |
| Genkwanin has antitumor, and anti-inflammatory activities, it enhances host immunity, decreases the inflammatory cytokine levels, and regulates the miR-101/MKP-1/MAPK pathway.Genkwanin may have anti-skin ageing activity, it can up-regulate the transcriptional activation of human type vii collagen gene promoter, stimulating the formation of anchoring fibrils at the basement membrane zone in skin contributed to preventing skin ageing; it also induces a decrease of melanin synthesis by inhibiting tyrosinase activity, it could as skin whitening agent in cosmetic preparations. | |
| BCN5489 | Dihydrorobinetin |
| (+)-Dihydrorobinetin is reported as a chemical marker of vinegars aged in acacia wood and can be used for authenticity purposes. | |
| BCN5492 | Gentianine |
| 1. Gentianine has anti-diabetic effect. 2. Gentianine has antipsychotic activity. 3. Gentianine has potential anti-inflammatory action, might be at least partly based on the suppressed production of TNF-alpha and IL-6. 4. Gentianine has diuretic activity, it could be developed as a safe antihypertensive drug. 5. Gentianine has hypotensive effect, it can produce a decrease in heart rate and systolic, diastolic and mean arterial blood pressure. 6. Gentianine has a protective effect on hippocampal CA1 neurons in rats subjected to recurrent febrile convulsion (FC), it can ameliorate FC-induced neuronal injury by enhancing glutamate acid decarboxylase activity, decreasing glutamate levels and increasing γ-aminobutyric acid levels. | |
| BCN5493 | 3-Phenyl-2-propen-1-ol |
| 1. The compounds 3-phenyl-2-propen-1-ol , 2-methyl-3-butyn-2-ol, 3,7-dimethylnonane, and 2-hydroxybenzoic acid occurred only during estrus which may be considered as marker for detection of estrus which would ultimately help for artificial insemination in captive condition. | |
| BCN5494 | Harmine |
| Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase ((DYRK)) inhibitor with neuroprotective, anticancer and anti-inflammatory activities. It regulates PPARγ expression through inhibition of the Wnt signaling pathway, it also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B. Harmine is able to induce beta cell proliferation, increase islet mass and improve glycemic control. Harmine induces apoptosis and inhibits proliferation, migration and invasion of human gastric cancer cells, which may be mediated by down-regulation of COX-2 expression. | |
| BCN5496 | Tabersonine |
| 1. Tabersonine is a precursor for vincristine used in cancer chemotherapy, the biocompatibility and small size essential for permeating the blood-brain barrier make it a potential therapeutic drug candidate for treating AD. | |
