Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3489 - 3496 of 9359 hot products
| Catalog No. | Product Name |
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| BCC8087 | PKI 14-22 amide, myristoylated |
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Cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).
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| BCC8088 | AEG 3482 |
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Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC<sub>50</sub> = 20 <span class='symbol'>μ</span>M).
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| BCC8089 | BI 78D3 |
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Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC<sub>50</sub> = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC<sub>50</sub> = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.
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| BCC8090 | BRD 7389 |
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Ribosomal S6 kinase (RSK) inhibitor (IC<sub>50</sub> values are 1.2, 1.5 and 2.4 <span class='symbol'>μ</span>M for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic <span class='symbol'>α</span>-cells.
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| BCC8091 | U 73343 |
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Analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTP<span class='symbol'>γ</span>S-induced Ca<sup>2+</sup> influx in hepatocytes.
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| BCC8092 | ML 141 |
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Allosteric inhibitor of Cdc42 GTPase (EC<sub>50</sub> = 2.1 <span class='symbol'>μ</span>M). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration <em>in vitro</em>.
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| BCC8093 | IQ 3 |
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Selective JNK3 inhibitor (K<sub>d</sub> values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-<span class='symbol'>κ</span>B/AP1 transcriptional activity in THP1-Blue cells (IC<sub>50</sub> = 1.4 <span class='symbol'>μ</span>M). Also inhibits TNF-<span class='symbol'>α</span> and IL-6 production <em>in vitro</em>.
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| BCC8094 | PF-04991532 |
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Potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.
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