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Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN5464	Skullcapflavone I
1. Skullcapflavone I selectively induces apoptosis in T-HSC/Cl-6 cells via caspase-3 and caspase-9 activation. 2. Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner.
BCN5465	Platyphyllonol
1. Platyphyllonol-5-xylopyranoside is moderately active against KBNP-0028 (H9N2) avian influenza virus as compared with zanamivir.
BCN5466	Hirsutanonol
1. Hirsutanonol or oregonin as an active ingredient composition for treating atopic dermatitis. 2. Hirsutanonol shows significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells. 3. Hirsutanonol has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation. 4. Hirsutanonol shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells. 5. Hirsutanonol has chemoprotective effect on human lymphocytes DNA. 6. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.
BCN5467	Hirsutenone
1. Hirsutenone exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2. 2. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity. 3. Hirsutenone may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. 4. Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation. 5. Hirsutenone shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells. 6. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.
BCN5474	Lacinilene C
1. Lacinilene C methyl ether elicits contraction of TSM by enhancing the movement of calcium through potential-dependent channels of smooth muscle cell membranes. 2. Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves.
BCN5475	Koaburaside
1. Koaburaside can suppress histamine release from mast cells, it may have anti-allergic inflammatory activity. 2. Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase.
BCN5476	Luteone
1.Luteone possesses antifungal activity sufficient to support its proposed role as pre-infectional resistance factors.
BCN5477	Acuminatin
1. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively. 2. (-)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the human cancer cells, therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents. 3. (-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant.