Epoxylathyrol

CAS# 28649-60-7

Epoxylathyrol

Catalog No. BCN5382----Order now to get a substantial discount!

Product Name & Size Price Stock
Epoxylathyrol: 5mg Please Inquire In Stock
Epoxylathyrol: 10mg Please Inquire In Stock
Epoxylathyrol: 20mg Please Inquire Please Inquire
Epoxylathyrol: 50mg Please Inquire Please Inquire
Epoxylathyrol: 100mg Please Inquire Please Inquire
Epoxylathyrol: 200mg Please Inquire Please Inquire
Epoxylathyrol: 500mg Please Inquire Please Inquire
Epoxylathyrol: 1000mg Please Inquire Please Inquire

Quality Control of Epoxylathyrol

Number of papers citing our products

Chemical structure

Epoxylathyrol

3D structure

Chemical Properties of Epoxylathyrol

Cas No. 28649-60-7 SDF Download SDF
PubChem ID 6443462 Appearance Powder
Formula C20H30O5 M.Wt 350.45
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1CC2(C(C1O)C(C3(CCC4C(C4(C)C)C=C(C2=O)C)CO3)O)O
Standard InChIKey VEFQDSXSELSHMX-YFHOEESVSA-N
Standard InChI InChI=1S/C20H30O5/c1-10-7-13-12(18(13,3)4)5-6-19(9-25-19)17(23)14-15(21)11(2)8-20(14,24)16(10)22/h7,11-15,17,21,23-24H,5-6,8-9H2,1-4H3/b10-7-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Epoxylathyrol

The seeds of Euphorbia lathyris L.

Biological Activity of Epoxylathyrol

Description1. Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells.

Epoxylathyrol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Epoxylathyrol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Epoxylathyrol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8535 mL 14.2674 mL 28.5347 mL 57.0695 mL 71.3369 mL
5 mM 0.5707 mL 2.8535 mL 5.7069 mL 11.4139 mL 14.2674 mL
10 mM 0.2853 mL 1.4267 mL 2.8535 mL 5.7069 mL 7.1337 mL
50 mM 0.0571 mL 0.2853 mL 0.5707 mL 1.1414 mL 1.4267 mL
100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.5707 mL 0.7134 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Epoxylathyrol

Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells.[Pubmed:26331763]

J Nat Prod. 2015 Sep 25;78(9):2215-28.

Epoxyboetirane A (1), a macrocyclic diterpene that was found to be inactive as an ABCB1 modulator, was submitted to several chemical transformations, aimed at generating a series of compounds with improved multidrug resistance (MDR)-modifying activity. Overall, 23 new derivatives were prepared, in addition to the already reported Epoxylathyrol (2) and methoxyboetirol (3). Their anti-MDR potential was assessed through both functional and chemosensitivity assays on resistant human colon adenocarcinoma and human ABCB1-gene transfected L5178Y mouse lymphoma cells. Structure-activity relationship analysis showed that different substitution patterns led to distinct ABCB1 inhibitory activities, although intrinsic cellular characteristics seemed to influence the modulatory behavior. A considerable enhancement in MDR-modifying activity was observed for aromatic compounds in both cell lines, particularly in 3,17-disubstituted esters derived from 3, a Payne-rearranged Michael adduct of 2. All compounds tested were revealed to interact synergistically with doxorubicin, and ATPase inhibition by three representative MDR-modifying compounds was also investigated. On account of its outstanding ABCB1 inhibitory activity at 0.2 muM and overall remarkable bioactive profile, methoxyboetirane B (22) was found to be a new promising lead for MDR-reversing anticancer drug development.

Keywords:

Epoxylathyrol,28649-60-7,Natural Products, buy Epoxylathyrol , Epoxylathyrol supplier , purchase Epoxylathyrol , Epoxylathyrol cost , Epoxylathyrol manufacturer , order Epoxylathyrol , high purity Epoxylathyrol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: