MeloscandonineCAS# 28645-27-4 |
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| Cas No. | 28645-27-4 | SDF | Download SDF |
| PubChem ID | 12082290 | Appearance | Powder |
| Formula | C20H20N2O2 | M.Wt | 320.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1S,10R,12R,13R,20S)-12-methyl-8,17-diazahexacyclo[11.6.1.110,13.01,10.02,7.017,20]henicosa-2,4,6,14-tetraene-9,11-dione | ||
| SMILES | CC1C(=O)C23CC14C=CCN5C4C2(CC5)C6=CC=CC=C6NC3=O | ||
| Standard InChIKey | RVVXEECWQBKQNP-DJKGFLTMSA-N | ||
| Standard InChI | InChI=1S/C20H20N2O2/c1-12-15(23)20-11-18(12)7-4-9-22-10-8-19(20,16(18)22)13-5-2-3-6-14(13)21-17(20)24/h2-7,12,16H,8-11H2,1H3,(H,21,24)/t12-,16-,18-,19+,20+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The root barks of Melodinus yunnanensis
Meloscandonine Dilution Calculator
Meloscandonine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1211 mL | 15.6055 mL | 31.211 mL | 62.422 mL | 78.0275 mL |
| 5 mM | 0.6242 mL | 3.1211 mL | 6.2422 mL | 12.4844 mL | 15.6055 mL |
| 10 mM | 0.3121 mL | 1.5605 mL | 3.1211 mL | 6.2422 mL | 7.8027 mL |
| 50 mM | 0.0624 mL | 0.3121 mL | 0.6242 mL | 1.2484 mL | 1.5605 mL |
| 100 mM | 0.0312 mL | 0.1561 mL | 0.3121 mL | 0.6242 mL | 0.7803 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Two new alkaloids from Melodinus hemsleyanus Diels.[Pubmed:26186199]
Nat Prod Res. 2016;30(2):162-7.
Two new monoterpenoid indole alkaloids, named 14,15-dihydro-14beta,15beta-epoxy-10-hydroxyscandine (1) and 15alpha-hydroxy-Meloscandonine (2), together with 12 known compounds, were isolated from the aerial parts of Melodinus hemsleyanus Diels. The structures of 1 and 2 were elucidated on the bases of 1D and 2D NMR spectra and MS. Two new compounds were evaluated for their PTP1B and Drak2 inhibitory effects, and inactivity.
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