Home >> Research Area >>Apoptosis>>Apoptosis Inducers>>Diterpenoids>> Atractylic acid dipotassium salt

Atractylic acid dipotassium salt

ANT inhibitor CAS# 102130-43-8

Atractylic acid dipotassium salt

2D Structure

Catalog No. BCN5384----Order now to get a substantial discount!

Product Name & Size Price Stock
Atractylic acid dipotassium salt: 5mg $219 In Stock
Atractylic acid dipotassium salt: 10mg Please Inquire In Stock
Atractylic acid dipotassium salt: 20mg Please Inquire Please Inquire
Atractylic acid dipotassium salt: 50mg Please Inquire Please Inquire
Atractylic acid dipotassium salt: 100mg Please Inquire Please Inquire
Atractylic acid dipotassium salt: 200mg Please Inquire Please Inquire
Atractylic acid dipotassium salt: 500mg Please Inquire Please Inquire
Atractylic acid dipotassium salt: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Atractylic acid dipotassium salt

3D structure

Package In Stock

Atractylic acid dipotassium salt

Number of papers citing our products

Chemical Properties of Atractylic acid dipotassium salt

Cas No. 102130-43-8 SDF Download SDF
PubChem ID 5702200 Appearance Powder
Formula C30H44K2O16S2 M.Wt 802.99
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility DMSO : 250 mg/mL (311.34 mM; Need ultrasonic)
H2O : 100 mg/mL (124.53 mM; Need ultrasonic)
SMILES CC(C)CC(=O)OC1C(C(C(OC1OC2CC(C3CCC45CC(CCC4C3(C2)C)C(=C)C5O)C(=O)O)CO)OS(=O)(=O)[O-])OS(=O)(=O)[O-].[K+].[K+]
Standard InChIKey IUCNQFHEWLYECJ-UAPRPQGYSA-L
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Atractylic acid dipotassium salt

The herbs of Atractylis gummifera

Biological Activity of Atractylic acid dipotassium salt

Description1. Atractyloside potassium salt inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane.

Atractylic acid dipotassium salt Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Atractylic acid dipotassium salt Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Atractylic acid dipotassium salt

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2453 mL 6.2267 mL 12.4535 mL 24.9069 mL 31.1336 mL
5 mM 0.2491 mL 1.2453 mL 2.4907 mL 4.9814 mL 6.2267 mL
10 mM 0.1245 mL 0.6227 mL 1.2453 mL 2.4907 mL 3.1134 mL
50 mM 0.0249 mL 0.1245 mL 0.2491 mL 0.4981 mL 0.6227 mL
100 mM 0.0125 mL 0.0623 mL 0.1245 mL 0.2491 mL 0.3113 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Atractylic acid dipotassium salt

Atractyloside Dipotassium Salt is an inhibitor of ADP/ATP Translocase.

ATP-ADP translocase (AAT) is a mitochondrial ADP/ATP carrier. It transports ATP from the mitochondrial matrix to the cytoplasm and transports ADP from the cytoplasm to the mitochondrial matrix.

In Ehrlich ascites tumor cells, atractyloside (3 mM) inhibited cells growth by 70%. The mitochondria became spherical shaped with translucent matrix rid of cristae. When transfered to normal medium, proliferation and macromolecular synthesis recovered to normal levels within 3 to 6 h [2].

In the sarcoplasmic reticulum vesicles from the rabbit skeletal muscle with 10 μM of cytoplasmic Ca2+, atractyloside reduced the rate of choline+ influx through the Ca2+ channels to 60%. Also, it inhibited about half of Ca2+ channels incorporated into planar bilayers [1]. In mitochondrial membranes isolated from a rat heart muscle, atractyloside (5-100 μM) inhibited the chloride channels in dose-dependent way [3].

References:
[1].  Yamaguchi N, Kagari T, Kasai M. Inhibition of the ryanodine receptor calcium channel in the sarcoplasmic reticulum of skeletal muscle by an ADP/ATP translocase inhibitor, atractyloside. Biochem Biophys Res Commun, 1999, 258(2): 247-251.
[2].  Pick-Kober KH, Schneider F. Proliferation, macromolecular synthesis and energy metabolism of in vitro grown Ehrlich ascites tumor cells after inhibition of ATP-ADP translocation by atractyloside. Eur J Cell Biol, 1984, 34(2): 323-329.
[3].  Malekova L, Kominkova V, Ferko M, et al. Bongkrekic acid and atractyloside inhibits chloride channels from mitochondrial membranes of rat heart. Biochim Biophys Acta, 2007, 1767(1): 31-44.

Featured Products
New Products
 

Description

Atractyloside potassium salt is a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum. Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart.

Keywords:

Atractylic acid dipotassium salt,102130-43-8,Natural Products,Apoptosis Inducers, buy Atractylic acid dipotassium salt , Atractylic acid dipotassium salt supplier , purchase Atractylic acid dipotassium salt , Atractylic acid dipotassium salt cost , Atractylic acid dipotassium salt manufacturer , order Atractylic acid dipotassium salt , high purity Atractylic acid dipotassium salt

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: