Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3401 - 3408 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7974 | TC Mps1 12 |
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Potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.
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| BCC7975 | SIB 1508Y maleate |
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Potent neuronal nicotinic ACh receptor agonist (EC<sub>50</sub> values are 1.8, 5, 9 and 23 nM for <span class='symbol'>α</span>4<span class='symbol'>β</span>2, <span class='symbol'>α</span>2<span class='symbol'>β</span>4, <span class='symbol'>α</span>4<span class='symbol'>β</span>4 and <span class='symbol'>α</span>3<span class='symbol'>β</span>4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease <em>in vivo</em>.
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| BCC7976 | ML 277 |
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Selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.
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| BCC7977 | Lu AA 47070 |
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Prodrug of a potent and selective adenosine A2A receptor antagonist (Ki values are 5.9, 260, 410 and <10,000 nM for A2A, A2B, A1 and A3 receptors respectively. Reverses parkinsonian motor impairment and motivational effects produced by dopamine D2 receptor blockade in rats. Orally bioavailable.
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| BCC7978 | Paprotrain |
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Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (K<sub>i</sub> = 3.4 <span class='symbol'>μ</span>M). Inhibits the basal ATPase activity of MKLP-2 (IC<sub>50</sub> = 1.35 <span class='symbol'>μ</span>M). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.
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| BCC7979 | 3-Cyano-7-ethoxycoumarin |
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Fluorescent P450 substrate (excitation/emission wavelengths = 408/455 nm); metabolized to cyano-hydroxycoumarin.
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| BCC7981 | TC-E 5006 |
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<span class='symbol'>γ</span>-secretase modulator. Reduces A<span class='symbol'>β</span>42 levels <em>in vitro</em> (EC<sub>50</sub> = 390 nM) and <em>in vivo</em>. Orally bioavailable.
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| BCC7982 | CEP 1347 |
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Inhibitor of c-jun N-terminal kinase (JNK) signaling. Rescues motor neurons undergoing apoptosis (EC<sub>50</sub> = 20 nM). Blocks A<span class='symbol'>β</span>-induced cortical neuron apoptosis (EC<sub>50</sub> ~51 nM). Does not inhibit ERK1 activity. Neuroprotective.
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