Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3305 - 3312 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7876 | ML 145 |
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Selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.
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| BCC7877 | MDL 100907 |
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Potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM). Exhibits > 80-fold selectivity for 5-HT2A over other serotonergic receptor subtypes. Antipsychotic agent in vivo.
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| BCC7878 | AS 1269574 |
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GPR119 receptor agonist (EC<sub>50</sub> = 2.5 <span class='symbol'>μ</span>M in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose <em>in vivo</em>. Stimulates proglucagon gene promoter actvity. Orally available.
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| BCC7879 | Sonepiprazole |
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Selective, high affinity antagonist for the rat and human dopamine D<sub>4</sub> receptor (K<sub>i</sub> = 10 nM). Exhibits low affinity at other monoamine receptors (K<sub>i</sub> > 2000 nM). Induces <em>c-fos</em> gene expression in medial prefrontal cortex in a similar manner to clozapine. Brain penetrant and orally available.
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| BCC7880 | SC 26196 |
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Selective <span class='symbol'>Δ</span>6 desaturase inhibitor (IC<sub>50</sub> = 0.2 <span class='symbol'>μ</span>M <em>in vitro</em>). Displays selectivity over <span class='symbol'>Δ</span>5 and <span class='symbol'>Δ</span>9 desaturases (IC<sub>50</sub> values are >200 <span class='symbol'>μ</span>M <em>in vitro</em>). Exhibits anti-inflammatory properties in a mouse edema model.
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| BCC7881 | CP 775146 |
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Selective, high affinity PPAR<span class='symbol'>α</span> agonist (K<sub>i</sub> values are 24.5 nM for PPAR<span class='symbol'>α</span> and >10 <span class='symbol'>μ</span>M for PPAR<span class='symbol'>β</span> and PPAR<span class='symbol'>γ</span> <em>in vitro</em>). Exhibits hypolipidemic activity <em>in vivo</em>.
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| BCC7882 | CP 100356 hydrochloride |
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High affinity P-glycoprotein (P-gp) inhibitor (K<sub>i</sub> values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC<sub>50</sub> = 0.5 <span class='symbol'>μ</span>M) and prazosin transport in BCRP-transfected MDCKII cells (IC<sub>50</sub> = 1.5 <span class='symbol'>μ</span>M). Displays weak or no inhibitory activity against MRP1, OATP1B1 and several major human P450 enzymes (IC<sub>50</sub> > 50 <span class='symbol'>μ</span>M).
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| BCC7883 | VPC 23019 |
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Sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
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