Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3145 - 3152 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7713 | SB 657510 |
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Selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively). Inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM).
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| BCC7714 | SB 612111 hydrochloride |
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Selective NOP receptor antagonist (K<sub>i</sub> values are 0.33, 57.6, 160.5 and 2109 nM for NOP, <span class='symbol'>μ</span>-, <span class='symbol'>κ</span>- and <span class='symbol'>δ</span>-receptors respectively). Antagonizes the pronociceptive action of nociceptin in an acute pain model. Potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model.
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| BCC7715 | VU 0155069 |
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Potent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.
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| BCC7716 | (±)-5'-Chloro-5'-deoxy-ENBA |
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Highly selective adenosine A1 receptor agonist (Ki values are 0.51, 1290, 1340 and 2740 nM at A1, A3, A2A and A2B receptors respectively). Reverses formaline-induced nocifensive behavior in mice; antinociceptive.
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| BCC7717 | 5-BDBD |
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Potent P2X<sub>4</sub> receptor antagonist. Blocks P2X<sub>4</sub>-mediated currents in Chinese hamster ovary cells (IC<sub>50</sub> = 0.50 <span class='symbol'>μ</span>M).
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| BCC7718 | Org 12962 hydrochloride |
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Selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.
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| BCC7719 | Estropipate |
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Estrogen receptor agonist. Also inhibits organic anion transporting polypeptide 1B1 (OATP1B1) (IC50= 70 nM).
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| BCC7720 | Indiplon |
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Potent GABA<sub>A</sub> receptor positive allosteric modulator that acts at the benzodiazepine site (K<sub>i</sub> values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for <span class='symbol'>α</span>1 subunit-containing receptors (EC<sub>50</sub> values are 2.6, 24, 60 and 77 nM for <span class='symbol'>α</span>1<span class='symbol'>β</span>2<span class='symbol'>γ</span>2, <span class='symbol'>α</span>2<span class='symbol'>β</span>2<span class='symbol'>γ</span>2, <span class='symbol'>α</span>3<span class='symbol'>β</span>3<span class='symbol'>γ</span>2 and <span class='symbol'>α</span>5<span class='symbol'>β</span>2<span class='symbol'>γ</span>2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity <em>in vivo</em> and is orally active.
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