Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2881 - 2888 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7445 | L-364,373 |
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Activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
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| BCC7446 | UCL 2077 |
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Slow afterhyperpolarization (sAHP) channel blocker; reduces sAHP in hippocampal slice preparations. Displays no effect on Ca<sup>2+</sup> currents or the time course of sAHP/sI<sub>AHP</sub>. Exhibits potent inhibition of KCNQ1 and KCNQ2, but differential effects at other KCNQs. Rescues memory retrieval in dopamine <span class='symbol'>β</span>-hydroxylase knockout mice.
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| BCC7447 | PHTPP |
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Selective estrogen ER<span class='symbol'>β</span> receptor antagonist that displays 36-fold selectivity over ER<span class='symbol'>α</span>. Exhibits full antagonism at ER<span class='symbol'>β</span> in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ER<span class='symbol'>α</span>.
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| BCC7448 | BMS 191011 |
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Potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).
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| BCC7449 | JP 1302 dihydrochloride |
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<span class='symbol'>α</span><sub>2C</sub>-adrenoceptor antagonist that displays ~ 50-fold selectivity over other <span class='symbol'>α</span><sub>2</sub>-adrenoceptor subtypes (K<sub>i</sub> values are 28, 1470, 1700 and 3150 nM for human <span class='symbol'>α</span><sub>2C</sub>, <span class='symbol'>α</span><sub>2B</sub>, <span class='symbol'>α</span><sub>2D</sub> and <span class='symbol'>α</span><sub>2A</sub> subtypes respectively). Potently antagonizes adrenalin-stimulated <sup>35</sup>GTP<span class='symbol'>γ</span>S binding <em>in vitro</em> (K<sub>B</sub> = 16 nM) and produces antidepressant and antipsychotic-like effects <em>in vivo</em>.
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| BCC7450 | TC 1 |
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High affinity <span class='symbol'>σ</span><sub>1</sub> receptor ligand that displays selectivity over <span class='symbol'>σ</span><sub>2</sub> receptors (K<sub>i</sub> values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (K<sub>i</sub> > 10 <span class='symbol'>μ</span>M) and low affinity for dopamine D<sub>2</sub> receptors (K<sub>i</sub> = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.
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| BCC7451 | Y 134 |
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Selective estrogen receptor modulator (SERM) that displays selectivity for ER<span class='symbol'>α</span> over ER<span class='symbol'>β</span> (K<sub>i</sub> values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.
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| BCC7452 | 17-PA |
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Selective antagonist of neurosteroid potentiation and direct gating of GABA<sub>A</sub> receptors. Selectively reduces the effects of 5<span class='symbol'>α</span>-reduced steroids compared to 5<span class='symbol'>β</span>-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3<span class='symbol'>α</span>,5<span class='symbol'>α</span>-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
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