Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2905 - 2912 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7470 | Org 20599 |
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Positive allosteric modulator and at higher concentrations direct agonist of GABA<sub>A</sub> receptors (EC<sub>50</sub> = 1.1 <span class='symbol'>μ</span>M). Also displays positive modulation of glycine receptors (EC<sub>50</sub> = 22.9 <span class='symbol'>μ</span>M). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.
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| BCC7471 | U 93631 |
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GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism.
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| BCC7472 | NNC 05-2090 hydrochloride |
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GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (K<sub>i</sub> values are 1.4, 15, 19 and 41 <span class='symbol'>μ</span>M for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at <span class='symbol'>α</span><sub>1</sub>- and D<sub>2</sub>-receptors (IC<sub>50</sub> values are 266 and 1632 nM respectively).
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| BCC7473 | MRS 1754 |
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Selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).
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| BCC7474 | B-HT 933 dihydrochloride |
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Selective <span class='symbol'>α</span>2-adrenoceptor agonist. Exhibits greater than 300-fold selectivity for the <span class='symbol'>α</span>2-adrenoceptor over the <span class='symbol'>α</span>1-adrenoceptor.
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| BCC7475 | L-748,337 |
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Competitive <span class='symbol'>β</span><sub>3</sub>-adrenoceptor antagonist that displays selectivity over <span class='symbol'>β</span><sub>1</sub> and <span class='symbol'>β</span><sub>2</sub> receptors (K<sub>i</sub> values are 4.0, 204 and 390 nM for <span class='symbol'>β</span><sub>3</sub>-, <span class='symbol'>β</span><sub>2</sub>- and <span class='symbol'>β</span><sub>1</sub>-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC<sub>50</sub> = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.
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| BCC7476 | Naspm trihydrochloride |
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Selective antagonist of Ca2+-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.
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| BCC7477 | L-365,260 |
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Selective cholecystokinin receptor 2 (CCK<sub>2</sub>) antagonist (IC<sub>50</sub> values are 2 and 280 nM at CCK<sub>2</sub> and CCK<sub>1</sub> receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, <span class='symbol'>α</span>- and <span class='symbol'>β</span> adrenergic, histamine, angiotensin and bradykinin receptors.
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