Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2873 - 2880 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7437 | L-703,664 succinate |
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5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).
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| BCC7438 | L-368,899 hydrochloride |
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Potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo.
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| BCC7439 | Co 102862 |
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Broad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures.
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| BCC7440 | Fananserin |
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5-HT<sub>2A</sub> receptor antagonist that also displays high affinity at D<sub>4</sub> receptors (K<sub>i</sub> values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT<sub>2A</sub>, D<sub>4</sub>, H<sub>1</sub>, <span class='symbol'>α</span><sub>1</sub>, 5-HT<sub>1A</sub> and D<sub>2</sub> receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT <em>in vitro</em> (IC<sub>50</sub> = 7.76 nM) and antagonizes mescaline-induced head twitches <em>in vivo</em>.
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| BCC7441 | HDS 029 |
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Potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).
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| BCC7442 | WAY 213613 |
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Potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.
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| BCC7443 | JX 401 |
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Potent, reversible inhibitor of p38<span class='symbol'>α</span> that displays no activity on the p38<span class='symbol'>γ</span> isoform (IC<sub>50</sub> values are 32 nM and > 10 <span class='symbol'>μ</span>M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
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| BCC7444 | Bucindolol |
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Non-selective β-adrenoceptor antagonist with additional α1-adrenoceptor blocking activity. Ki values are 1.61, 1.20 and 68.9 nM for β1-, β2- and α1-adrenoceptors respectively. Also acts as a weak 5-HT2A/2B antagonist. Displays vasodilatory and antihypertensive actions.
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