Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4544 | 4'-Hydroxyacetophenone |
| 4'-Hydroxyacetophenone is a potent xanthine oxidase inhibitor, three 4′-hydroxyacetophenone-related phytoalexins from Polymnia sonchifolia have antifungal activity. | |
| BCN4545 | Isoboonein |
| 1. Isoboonein exhibits significant antitumor and antibacterial activity. | |
| BCN4546 | 4-Hydroxybenzoic acid |
| 4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a phenolic derivative of benzoic acid and widely used in organic synthesis. 4-Hydroxybenzoic acid derivatives has potential to as pan-HDAC inhibitors with anticancer properties. 4-Hydroxybenzoic acid positively regulates the expression of gum cluster to promote EPS production in PXO99A; it can inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL. | |
| BCN4547 | Uncinatone |
| 1. Uncinatone exhibits inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 12.50 uM. 2. Uncinatone shows inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 87 uM. 3. Uncinatone demonstrates cytotoxic activities against the HL-60 tumour cell line (IC50 ＜ 20 uM). 4. Uncinatone exhibits moderate cytotoxicity, inhibits cell proliferation, and induces cell-cycle G(2)/M phase arrest. | |
| BCN4549 | 2',3'-Dehydrosalannol |
| 1. 2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. 2. 2'-3'-Dehydrosalannol shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits cathepsin-mediated pro-survival signaling which resulted in growth arrest of TNBC cells. | |
| BCN4554 | Isolicoflavonol |
| 1. Isolicoflavonol is a potential cancer chemopreventive agent. | |
| BCN4557 | Furan-2-carboxylic acid |
| Furan-2-carboxylic acid, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.Furan-2-carboxylic acid also has anti-bacterial effect, inhibits the proliferation of some slow-growing or difficult-to-culture bacteria on the plates. | |
| BCN4558 | Denudatin B |
| 1. Denudatin B inhibits the aggregation and ATP release of washed rabbit platelets caused by platelet-activating factor (PAF) in a concentration-dependent manner. 2. Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin. 3. Denudatin B relaxes vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels; its effect to increase cGMP may enhance the vasorelaxation. 4. Denudatin B shows potent 2, 2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activity. | |
