Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2865 - 2872 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7429 | PD 144418 oxalate |
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High affinity, selective <span class='symbol'>σ</span><sub>1</sub> ligand (K<sub>i</sub> values are 0.08 and 1377 nM for <span class='symbol'>σ</span><sub>1</sub> and <span class='symbol'>σ</span><sub>2</sub> respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.
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| BCC7430 | CI 988 |
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Potent and selective CCK<sub>2</sub> (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK<sub>1</sub> receptors (IC<sub>50</sub> values are 1.7 and 2717 nM for CCK<sub>2</sub> and CCK<sub>1</sub> respectively). Has negligible affinity at a range of other binding sites (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Exhibits anxiolytic activity following oral administration.
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| BCC7431 | PD 135158 |
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Potent and selective, nonpeptide CCK<sub>2</sub> receptor antagonist (IC<sub>50</sub> values are 2.8 and 1232 nM for CCK<sub>2</sub> and CCK<sub>1</sub> respectively) that displays negligible affinity at GABA<sub>A</sub>, benzodiazepine, substance P, neurotensin, opioid, bradykinin and 5-HT<sub>3</sub> receptors (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Exhibits anxiolytic activity in elevated plus maze and social interaction tests and increases food intake in rats.
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| BCC7432 | Ryuvidine |
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Inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC<sub>50</sub> = 0.5 <span class='symbol'>μ</span>M); suppresses H4K20 monomethylation <em>in vitro</em>. Also inhibits cyclin-dependent kinase (CDK) 4 (IC<sub>50</sub> = 6.0 <span class='symbol'>μ</span>M at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.
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| BCC7433 | RWJ 56110 |
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Selective protease-activated receptor-1 (PAR<sub>1</sub>) antagonist; displays no activity at PAR<sub>2</sub>, PAR<sub>3</sub>, or PAR<sub>4</sub> subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model <em>in vivo</em>.
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| BCC7434 | PD 158780 |
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Potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.
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| BCC7435 | NGB 2904 |
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Potent and selective dopamine D<sub>3</sub> receptor antagonist (K<sub>i </sub>values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D<sub>3</sub>, D<sub>2</sub>, 5-HT<sub>2</sub>, <span class='symbol'>α</span><sub>1</sub>, D<sub>4</sub>, D<sub>1</sub> and D<sub>5</sub> receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC<sub>50</sub> = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.
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| BCC7436 | ST 91 |
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<span class='symbol'>α</span><sub>2</sub>-adrenoceptor agonist that does not cross the blood brain barrier. Displays ~ 120-fold selectivity for <span class='symbol'>α</span><sub>2</sub> receptors over <span class='symbol'>α</span><sub>1</sub> receptors and acts predominantly at non-<span class='symbol'>α</span><sub>2A</sub>-adrenoceptors which may be of the <span class='symbol'>α</span><sub>2C</sub> subtype. Antinociceptive; increases tail-flick latencies in Sasco and Harlan rats.
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