Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2825 - 2832 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7389 | J 104129 fumarate |
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Potent M<sub>3</sub> muscarinic receptor antagonist that displays ~ 120-fold selectivity over M<sub>2</sub> receptors (K<sub>i</sub> values are 4.2, 19 and 490 nM for human M<sub>3</sub>, M<sub>1</sub> and M<sub>2</sub> receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (K<sub>B</sub> values are 3.3 and 170 nM for rat trachea M<sub>3</sub> and rat right atria M<sub>2</sub> receptors respectively).
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| BCC7390 | Trap 101 |
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Potent and selective nociceptin/orphanin FQ (NOP) receptor antagonist (pA<sub>2</sub> = 7.75). Displays selectivity for NOP receptors over classical opioid receptors (pK<sub>i</sub> values are 8.65, 6.60, 6.14 and < 5 for NOP, <span class='symbol'>μ</span>-, <span class='symbol'>κ</span>-, and <span class='symbol'>δ</span>-opioid receptors respectively). Attenuates motor deficits in a rat model of Parkinson's Disease. Active <em>in vivo</em>.
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| BCC7391 | Talniflumate |
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Calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
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| BCC7392 | APC 366 |
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Selective inhibitor of mast cell tryptase (K<sub>i</sub> = 7.1 <span class='symbol'>μ</span>M) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness <em>in vivo</em>.
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| BCC7393 | L-161,982 |
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EP<sub>4</sub> receptor antagonist that is selective over all other members of the prostanoid receptor family (K<sub>i</sub> values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 <span class='symbol'>μ</span>M for human EP<sub>4</sub>, TP, EP<sub>3</sub>, DP, FP, IP, EP<sub>1</sub> and EP<sub>2</sub> receptors respectively). Suppresses PGE<sub>2</sub>-induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice.
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| BCC7394 | TC 1698 dihydrochloride |
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Selective nicotinic <span class='symbol'>α</span>7 receptor agonist (EC<sub>50</sub> = 440 nM). Also displays weak partial agonist/antagonist activity at <span class='symbol'>β</span>-subunit-containing receptors. Neuroprotective.
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| BCC7395 | T 98475 |
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Potent, orally active and non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 values are 0.2, 4.0 and 60 nM for human, monkey and rat GnRH receptors respectively). Inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys.
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| BCC7396 | YM 26734 |
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Competitive inhibitor of secretory phospholipase A<sub>2</sub> (sPLA<sub>2</sub>) that exhibits a broad inhibitory profile to several sPLA<sub>2</sub>s (IC<sub>50</sub> values are 0.2, 1, 1, 1 and 3 <span class='symbol'>μ</span>M for sPLA<sub>2</sub>-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA<sub>2</sub>-IIF and no activity at cytosolic PLA<sub>2</sub>, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
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