Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2769 - 2776 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7332 | JNJ 16259685 |
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Sub-nanomolar potent, non-competitive mGlu<sub>1</sub> antagonist (K<sub>i</sub> = 0.34 nM). Inhibits glutamate-induced Ca<sup>2+</sup> response at the human mGlu<sub>1</sub> receptor with an IC<sub>50</sub> value of 0.55 nM. Selective over mGlu<sub>5</sub> (> 400-fold) and displays no activity at mGlu<sub>2</sub>, mGlu<sub>3</sub>, mGlu<sub>4</sub>, mGlu<sub>6</sub>, AMPA or NMDA receptors (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Centrally active following systemic administration.
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| BCC7333 | Trequinsin hydrochloride |
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Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models.
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| BCC7334 | MK 571 |
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Potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.
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| BCC7335 | WEB 2086 |
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Potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.
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| BCC7336 | A 80426 mesylate |
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High affinity <span class='symbol'>α</span><sub>2</sub>-adrenoceptor antagonist and selective 5-HT uptake inhibitor (K<sub>i</sub> values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.
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| BCC7337 | 4-Methylhistamine dihydrochloride |
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Potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
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| BCC7338 | CGH 2466 dihydrochloride |
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Adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.
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| BCC7339 | ZK 200775 |
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Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [<sup>3</sup>H]-AMPA (K<sub>i</sub> = 120 nM) and [<sup>3</sup>H]-CNQX (K<sub>i</sub> = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC<sub>50</sub> values range from 2.5 to 11 <span class='symbol'>μ</span>M). Inhibits currents induced by AMPA, kainate and NMDA with IC<sub>50</sub> values of 21 nM, 27 nM, and > 1 <span class='symbol'>μ</span>M respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity <em>in vivo</em>.
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