Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4314 | Lupalbigenin |
| 1. Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins. 2. Lupalbigenin, laburnetin , and isolupalbigenin show promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM). | |
| BCN4315 | Quassin |
| 1. Quassin exhibits P. falciparum inhibitory activity (IC50=0.06 micro g/ml, 0.15 micro M). 2. Quassin can significantly increase red blood cell count, pack cell volume and haemoglobin concentration, suggests that it possesses anti-anaemic property. 3. Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion. 4. Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity. | |
| BCN4317 | Mallorepine |
| 1. Mallorepine may propably be an intermediate on the biosynthetic pathway from nicotinamide (II) to ricinine (III). | |
| BCN4318 | Camptothecin |
| Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM; it is a novel alkaloidal leukemia and tumor inhibitor, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand breaks in chromosomal DNA. Camptothecin and its analogs reduce amyloid-β production and amyloid-β42-induced IL-1β production. | |
| BCN4320 | Cleomiscosin A |
| 1. Cleomiscosin A and brusatol are antitumor agents, have antileukemic principles. 2. Cleomiscosin A has antioxidant activity, it could be beneficial in preventing LDL oxidation in atherosclerotic lesions. 3. Cleomiscosin A methyl ether derivatives have anti-inflammatory activity. 4. Cleomiscosin A shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. 5. The mixture of three compounds (cleomiscosin A, B and C) is showing the significant protective effects against CCl(4)-induced hepatotoxicity in small animals and also coumarinolignoids are well tolerated by small animals in acute oral study. | |
| BCN4321 | 15-Methoxypinusolidic acid |
| 1. 15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression. 2. 15-Methoxypinusolidic acid inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB, suggesting a potential anti-inflammatory effect of the compound on microglial cells. 3. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression. 4. 15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors. | |
| BCN4322 | Garcinone C |
| 1. Garcinone C is the most potent inhibitor of AChE. 2. Garcinone C is the most active compound against both of pathogenic (MIC =100 μg/ml) and non-pathogenic leptospira (MIC = 200 μg/ml). 3. Garcinone C exhibits either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro. | |
| BCN4324 | 1H-Indole-3-carboxylic acid |
| Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite which belongs to a class of organic compounds known as indolecarboxylic acids and derivatives. | |
