Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2689 - 2696 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7252 | SKF 83822 hydrobromide |
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High affinity, selective dopamine D<sub>1</sub>-like receptor agonist. K<sub>i</sub> values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D<sub>1</sub>, D<sub>5</sub>, D<sub>2</sub>, D<sub>3</sub>, D<sub>4</sub>, 5-HT<sub>2A</sub>, <span class='symbol'>α</span><sub>1A</sub> and <span class='symbol'>α</span><sub>1B</sub> receptors respectively. Stimulates adenylyl cyclase (EC<sub>50</sub> = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
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| BCC7253 | Y-26763 |
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K<sub>ir</sub>6 (K<sub>ATP</sub>) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC<sub>50</sub> = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic <span class='symbol'>β</span>-cells <em>in vitro</em>. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration <em>in vivo</em>.
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| BCC7254 | Y-27152 |
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Prodrug of the K<sub>ir</sub>6 (K<sub>ATP</sub>) channel opener Y-26763. Inactive <em>in vitro</em>; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects <em>in vivo</em>, with minimal tachycardia following oral administration in hypertensive animals.
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| BCC7255 | UBP 296 |
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Selective GluR5-subunit containing kainate receptor antagonist (apparent K<sub>D</sub> = 1.09 <span class='symbol'>μ</span>M). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Active enantiomer UBP 302 available.
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| BCC7256 | UBP 302 |
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Potent and selective GLU<sub>K5</sub> (GluR5)-subunit containing kainate receptor antagonist (apparent K<sub>D</sub> = 402 nM); active enantiomer of UBP 296. Displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GLU<sub>K6</sub>- and GLU<sub>K2</sub>-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.
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| BCC7257 | Exendin-3 (9-39) amide |
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Potent and selective GLP-1 receptor antagonist (Kd = 1.7 nM at cloned human GLP-1 receptors). Inhibits cAMP production and insulin release induced by GLP-1 (7-36), exendin-3 (IC50 = 20 nM) and exendin-4. Blocks the inhibitory effect of GLP-1 on food intake in rats.
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| BCC7258 | Glucagon-like peptide 1 (7-36) amide (human, rat) |
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Potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (K<sub>d</sub> = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic <span class='symbol'>β</span>-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.
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| BCC7259 | DMNB |
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Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC<sub>50</sub> = 15 <span class='symbol'>μ</span>M), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.
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