Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4186 | Mussaenoside |
| 1. Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB. 2. Mussaenoside can inhibit the release of pro-inflammatory cytokines induced by LPS, the production of nitric oxide (NO) and prostaglandin E2, and the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysaccharide (LPS) in the RAW264.7 murine macrophage cell line. | |
| BCN4187 | Shanzhiside methylester |
| Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling. | |
| BCN4188 | Coleonol B |
| Coleonol B a natural product from Coleus forskohlii. | |
| BCN4189 | Tetrahydroalstonine |
| Tetrahydroalstonine and Raubasine preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to exogenous and endogenouse noradrenaline, respectively. | |
| BCN4193 | Sendanolactone |
| 1. Sendanolactone possesses moderate cytotoxic activity against KB cell lines. | |
| BCN4196 | Dehydrocrenatidine |
| 1. Dehydrocrenatidine is a JAK-specific inhibitor, can inhibit JAK-STAT3-dependent DU145 and MDA-MB-468 cell survival and induce cell apoptosis. 2. Dehydrocrenatidine inhibits JAK2-JH1 kinase activity in vitro , represses constitutively activated JAK2 and STAT3, as well as interleukin-6-, interferon-α-, and interferon-γ-stimulated JAK activity, and STAT phosphorylation, and suppresses STAT3 and STAT1 downstream gene expression. | |
| BCN4198 | Phebalosin |
| 1. Phebalosin displays 50% effective concentrations (EC(50)) of 14.1 microg/mL against axenic amastigote forms of Leishmania panamensis. 2. Phebalosin displays cytotoxicity (IC(50)) at concentrations of 20.7 microg/mL on human promonocytic U-937 cells. | |
| BCN4199 | Cerbinal |
| 1. Cerbinal is a potent antifungal compound. | |
