Hot Natural Products & Bioactive Compounds

BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.

Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.

Hot Products from BioCrick

Showing 2673 - 2680 of 9359 hot products

BioCrick hot natural products and bioactive compounds
Catalog No. Product Name
BCC7235 Paxilline
Potent blocker of high-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> (BK<sub>Ca</sub>, K<sub>Ca</sub>1.1) channels. Binds to the <span class='symbol'>&alpha;</span>-subunit of BK<sub>Ca</sub> (K<sub>i</sub> = 1.9 nM for block of currents in <span class='symbol'>&alpha;</span>-subunit-expressing oocytes) and enhances binding of charybdotoxin to BK<sub>Ca</sub> channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase (IC<sub>50</sub> = 5 - 50 <span class='symbol'>&mu;</span>M).
BCC7236 SKF 86002 dihydrochloride
Inhibitor of p38 MAP kinase (IC<sub>50</sub> = 0.1 - 1 <span class='symbol'>&mu;</span>M). Potently inhibits LPS-induced IL-1 and TNF-<span class='symbol'>&alpha;</span> production in human monocytes (IC<sub>50</sub> = 1 <span class='symbol'>&mu;</span>M). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC<sub>50</sub> values are 10 and 100 <span class='symbol'>&mu;</span>M respectively). Anti-inflammatory following oral administration <em>in vivo</em>.
BCC7237 PSB 1115
Highly selective, water-soluble, human A2B adenosine receptor antagonist. Ki values are 53.4, > 10000 and > 10000 nM at human A2B, A1 and A3 receptors respectively. Also selective versus rat A1 and A2A receptors (Ki values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo.
BCC7238 PSB 10 hydrochloride
Potent and highly selective antagonist for the human adenosine A<sub>3</sub> receptor, with low affinity for the rat A<sub>3</sub> receptor (K<sub>i</sub> values are 0.44 and &gt; 17000 nM respectively). Displays &gt; 3800-fold selectivity over human A<sub>1</sub>, A<sub>2A</sub> and A<sub>2B</sub> receptors (K<sub>i</sub> values are 4.1, 3.3 and 30 <span class='symbol'>&mu;</span>M respectively) and &gt; 1800-fold selectivity over rat A<sub>1</sub> and A<sub>2A</sub> receptors. Acts as an inverse agonist in the [<sup>35</sup>S]GTP<span class='symbol'>&gamma;</span>S binding assay in hA<sub>3</sub>-CHO cells (IC<sub>50</sub> = 4 nM). Produces thermal hyperalgesia in mice <em>in vivo</em>.
BCC7239 PSB 11 hydrochloride
Potent and selective antagonist for the human adenosine A<sub>3</sub> receptor, with low affinity for the rat A<sub>3</sub> receptor (K<sub>i</sub> values are 2.3 and &gt; 10000 nM respectively). Displays &gt; 1000-fold selectivity over human A<sub>1</sub> and A<sub>2A</sub> receptors (K<sub>i</sub> values are 4.1 and 3.3 <span class='symbol'>&mu;</span>M respectively) and &gt; 180-fold selectivity over rat A<sub>1</sub>, rat A<sub>2A</sub> and mouse A<sub>2B</sub> receptors. Acts as an inverse agonist in the [<sup>35</sup>S]GTP<span class='symbol'>&gamma;</span>S binding assay in hA<sub>3</sub>-CHO cells (IC<sub>50</sub> = 36 nM).
BCC7240 PSB 36
Potent and selective A<sub>1</sub> adenosine receptor antagonist. Displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA<sub>1</sub>, hA<sub>2B</sub>, rA<sub>2A</sub>, rA<sub>3</sub> and hA<sub>3</sub> receptors respectively. Demonstrates greater selectivity than DPCPX).
BCC7241 Ch 55
Highly potent synthetic retinoid that has high affinity for RAR-<span class='symbol'>&alpha;</span> and RAR-<span class='symbol'>&beta;</span> receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC<sub>50</sub> values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC<sub>50</sub> values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC<sub>50</sub> = 1 nM).
BCC7242 LE 135
Retinoic acid antagonist; displays moderate selectivity for RARβ over RARα (Ki values are 0.22 and 1.4 μM respectively). Highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM).