Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2681 - 2688 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7243 | SR 202 |
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Selective PPAR<span class='symbol'>γ</span> antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPAR<span class='symbol'>γ</span> transcriptional activity (IC<sub>50</sub> = 140 <span class='symbol'>μ</span>M) without affecting ligand-stimulated PPAR<span class='symbol'>α</span>, PPAR<span class='symbol'>β</span> or FXR transcriptional activity. Inhibits PPAR<span class='symbol'>γ</span>-dependent adipocyte differentiation and growth <em>in vitro</em> and <em>in vivo</em>. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats <em>in vivo</em>.
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| BCC7244 | Cinalukast |
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Potent, selective CysLT1 (LTD4) leukotriene receptor antagonist (IC50 = 6.4 nM). Inhibits LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.
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| BCC7245 | ROS 234 dioxalate |
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Potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).
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| BCC7246 | SDZ 205-557 hydrochloride |
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5-HT3/5-HT4 receptor antagonist.
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| BCC7247 | Iloprost |
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Prostacyclin (PGI<sub>2</sub>) analog that binds with high affinity to IP, EP<sub>1</sub> and EP<sub>3</sub> receptors (K<sub>i</sub> values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP<sub>1</sub>, EP<sub>3</sub>, EP<sub>4</sub>, FP, DP, EP<sub>2</sub> and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC<sub>50</sub> values are 0.24, 0.71 and 1.07 nM respectively).
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| BCC7249 | Aminopurvalanol A |
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Cell-permeable cyclin-dependent kinase inhibitor. IC<sub>50</sub> values are 0.033, 0.033, 0.028 and 0.020 <span class='symbol'>μ</span>M for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC<sub>50</sub> = 12.0 <span class='symbol'>μ</span>M) and ERK2 (IC<sub>50</sub> = 3.1 <span class='symbol'>μ</span>M) and is 3000-fold selective over a range of other protein kinases (IC<sub>50</sub> > 100 <span class='symbol'>μ</span>M). Arrests cell cycle at G<sub>2</sub>/M boundary (IC<sub>50</sub> = 1.25 <span class='symbol'>μ</span>M), and induces apoptosis at concentrations > 10 <span class='symbol'>μ</span>M.
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| BCC7250 | (R)-(-)-Apomorphine hydrochloride |
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Prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo.
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| BCC7251 | SKF 83959 hydrobromide |
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Dopamine D<sub>1</sub>-like receptor partial agonist (K<sub>i</sub> values are 1.18, 7.56, 920 and 399 nM for rat D<sub>1</sub>, D<sub>5</sub>, D<sub>2</sub> and D<sub>3</sub> receptors respectively). May act as an antagonist <em>in vivo</em>, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the <span class='symbol'>σ</span><sub>1</sub> receptor.
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