Home >> Research Area >>GPCR/G protein>>5-HT Receptor>> SDZ 205-557 hydrochloride

SDZ 205-557 hydrochloride

5-HT4/5-HT3 receptor antagonist CAS# 1197334-02-3

SDZ 205-557 hydrochloride

Catalog No. BCC7246----Order now to get a substantial discount!

Product Name & Size Price Stock
SDZ 205-557 hydrochloride: 5mg $81 In Stock
SDZ 205-557 hydrochloride: 10mg Please Inquire In Stock
SDZ 205-557 hydrochloride: 20mg Please Inquire Please Inquire
SDZ 205-557 hydrochloride: 50mg Please Inquire Please Inquire
SDZ 205-557 hydrochloride: 100mg Please Inquire Please Inquire
SDZ 205-557 hydrochloride: 200mg Please Inquire Please Inquire
SDZ 205-557 hydrochloride: 500mg Please Inquire Please Inquire
SDZ 205-557 hydrochloride: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of SDZ 205-557 hydrochloride

Number of papers citing our products

Chemical structure

SDZ 205-557 hydrochloride

3D structure

Chemical Properties of SDZ 205-557 hydrochloride

Cas No. 1197334-02-3 SDF Download SDF
PubChem ID 11957705 Appearance Powder
Formula C14H22Cl2N2O3 M.Wt 337.25
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in water
Chemical Name 2-(diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate;hydrochloride
SMILES CCN(CC)CCOC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl
Standard InChIKey JOWUQCJWCRNVMQ-UHFFFAOYSA-N
Standard InChI InChI=1S/C14H21ClN2O3.ClH/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3;/h8-9H,4-7,16H2,1-3H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of SDZ 205-557 hydrochloride

Description5-HT3/5-HT4 receptor antagonist.

SDZ 205-557 hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

SDZ 205-557 hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of SDZ 205-557 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9652 mL 14.8258 mL 29.6516 mL 59.3032 mL 74.129 mL
5 mM 0.593 mL 2.9652 mL 5.9303 mL 11.8606 mL 14.8258 mL
10 mM 0.2965 mL 1.4826 mL 2.9652 mL 5.9303 mL 7.4129 mL
50 mM 0.0593 mL 0.2965 mL 0.593 mL 1.1861 mL 1.4826 mL
100 mM 0.0297 mL 0.1483 mL 0.2965 mL 0.593 mL 0.7413 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on SDZ 205-557 hydrochloride

Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell.[Pubmed:10490917]

J Pharmacol Exp Ther. 1999 Oct;291(1):300-7.

The localization of 5-hydroxytryptamine(4) (5-HT(4)) receptors suggests their role in the regulation of dopamine (DA) neurotransmission, a speculation that has been supported by neurochemical studies. Mesolimbic DA systems play a prominent role in mediating the behavioral effects of the abused psychostimulant cocaine, and the intent of the present study was to assess the role of 5-HT(4) receptors in the control of spontaneous and cocaine-induced activity. Systemic administration of the 5-HT(4) receptor partial agonist 1-(4-amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]1-propa none hydrochloride (RS 67333; 0.0001-1 mg/kg) or the 5-HT(4) receptor antagonist 4-amino-5-chloro-2-methoxy-benzoic acid-(diethylamino)ethyl ester hydrochloride (SDZ 205,557; 0.0001-1 mg/kg) did not significantly alter spontaneous activity, whereas SDZ 205,557 significantly attenuated cocaine-induced horizontal activity and rearing. To test the hypothesis that cocaine-elicited behaviors were modulated by 5-HT(4) receptors in the nucleus accumbens (NAc) shell, two separate groups of male rats were implanted with bilateral cannulas aimed at the NAc shell. Intra-NAc shell microinjections of either RS 67333 (1 or 3 microgram/0.2 microliter/side) or SDZ 205,557 (1-5 microgram/0.2 microliter/side) did not alter spontaneous activity observed after a systemic saline injection but did significantly attenuate the hyperactivity induced by systemic cocaine injection (10 mg/kg). These results support an involvement of 5-HT(4) receptors, particularly those in the NAc shell, in the locomotor stimulatory effects of cocaine. Furthermore, these data suggest that 5-HT(4) receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.

The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors.[Pubmed:8448587]

Br J Pharmacol. 1993 Feb;108(2):376-82.

1. The interaction of the novel antagonist, SDZ 205,557 (2-methoxy-4-amino-5-chloro benzoic acid 2-(diethylamino) ethyl ester), at 5-HT3 and 5-HT4 receptors has been assessed in vitro and in vivo. 2. In guinea-pig hippocampus and in the presence of 0.4 microM 5-carboxamidotryptamine, 5-HT4-mediated stimulation of adenylyl cyclase was competitively antagonized by SDZ 205,557, with a pA2 value of 7.5, and a Schild slope of 0.81. In rat carbachol-contracted oesophagus, 5-HT4-receptor mediated relaxations were surmountably antagonized by SDZ 205,557 with a similar pA2 value (7.3). This value was agonist-independent with the exception of (R)-zacopride, against which a significantly lower value (6.4) was observed. 3. In functional studies of 5-HT3 receptors, SDZ 205,557 exhibited an affinity of 6.2 in guinea-pig ileum compared with 6.9 at binding sites labelled by [3H]-quipazine in NG108-15 cells. In the anaesthetized, vagotomized micropig, SDZ 205,557 produced only a transient blockade of 5-HT4-mediated tachycardia. This contrasted with tropisetron, which was active for over 60 min after administration. The half-lives for the inhibitory responses of SDZ 205,557 and tropisetron were 23 and 116 min, respectively. 4. In conclusion, SDZ 205,557 has similar affinity for 5-HT3 and 5-HT4 receptors. The apparent selectivity observed in guinea-pig is due to the atypical nature of the 5-HT3 receptor in this species. The short duration of action of this novel antagonist may complicate its use in vivo. SDZ 205,557 should, therefore, be used with appropriate caution in studies defining the 5-HT4 receptor.

Keywords:

SDZ 205-557 hydrochloride,1197334-02-3,Natural Products,5-HT Receptor, buy SDZ 205-557 hydrochloride , SDZ 205-557 hydrochloride supplier , purchase SDZ 205-557 hydrochloride , SDZ 205-557 hydrochloride cost , SDZ 205-557 hydrochloride manufacturer , order SDZ 205-557 hydrochloride , high purity SDZ 205-557 hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: