Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2625 - 2632 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7185 | Indirubin-3'-oxime |
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Protein kinase inhibitor; inhibits cyclin-dependent kinases (IC<sub>50</sub> = 0.18 - 3.33 <span class='symbol'>μ</span>M) and GSK-3<span class='symbol'>β</span> (IC<sub>50</sub> = 0.19 <span class='symbol'>μ</span>M). Inhibits CDK5- and GSK-3<span class='symbol'>β</span>-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.
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| BCC7186 | N-ArachidonylGABA |
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Arachidonyl amino acid; first isolated from bovine brain. Inhibits pain in vivo.
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| BCC7187 | Palmitoylisopropylamide |
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Inhibitor of fatty acid amide hydrolase (FAAH); pIC<sub>50</sub> = 4.89 for inhibition of [<sup>3</sup>H]-anandamide metabolism. Displays little binding to CB<sub>1</sub> and CB<sub>2</sub> receptors (IC<sub>50</sub> > 100 <span class='symbol'>μ</span>M) and very weakly blocks anandamide uptake (IC<sub>50</sub> ~ 100 <span class='symbol'>μ</span>M). Inhibits proliferation of C6 glioma cells.
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| BCC7188 | ICI 63197 |
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Potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.
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| BCC7189 | Demethylasterriquinone B1 |
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Selective insulin receptor (IR) activator (EC<sub>50</sub> values are 3 - 6 <span class='symbol'>μ</span>M for IRTK and 100 <span class='symbol'>μ</span>M for IGF1R and EGFR). Increases IR <span class='symbol'>β</span> subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle <em>in vitro</em>, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.
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| BCC7190 | YM 976 |
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Orally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
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| BCC7191 | Seglitide |
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Peptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5).
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| BCC7192 | IRL-2500 |
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Potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
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