Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2609 - 2616 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7168 | ALX 5407 hydrochloride |
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Selective non-transportable inhibitor of the glycine transporter GlyT1 (IC<sub>50</sub> values are 3 nM and > 100 <span class='symbol'>μ</span>M for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC<sub>50</sub> > 100 <span class='symbol'>μ</span>M).
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| BCC7169 | (±)-Blebbistatin |
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Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
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| BCC7170 | Acifran |
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Hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50 values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.
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| BCC7171 | UBP 282 |
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AMPA and kainate receptor antagonist. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres.
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| BCC7172 | UBP 301 |
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Potent kainate receptor antagonist (apparent K<sub>d</sub> = 5.94 <span class='symbol'>μ</span>M). Displays ~ 30-fold selectivity over AMPA receptors.
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| BCC7173 | Zimelidine dihydrochloride |
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5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC<sub>50</sub> values are 0.33, 8.2 and 12 <span class='symbol'>μ</span>M respectively). Modulates nociception and induces hyperglycemia <em>in vivo</em>, and is an orally active antidepressant.
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| BCC7174 | S 14506 hydrochloride |
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Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.
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| BCC7175 | Ro 106-9920 |
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Inhibitor of NF-<span class='symbol'>κ</span>B activation, possibly via selective inhibition of LPS- and TNF-<span class='symbol'>α</span>-induced I<span class='symbol'>κ</span>B<span class='symbol'>α</span> ubiquitination (IC<sub>50</sub> = 3 <span class='symbol'>μ</span>M). Blocks subsequent production of TNF-<span class='symbol'>α</span>, IL-1<span class='symbol'>β</span> and IL-6. Inhibits mucin production in an <em>in vitro</em> model of COPD, and is anti-inflammatory following oral administration <em>in vivo</em>. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
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