Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2577 - 2584 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7135 | IEM 1460 |
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Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca<sup>2+</sup>-permeable) receptors over GluR2-containing receptors (IC<sub>50</sub> values are 2.6 and 1102 <span class='symbol'>μ</span>M, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant <em>in vivo</em>.
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| BCC7136 | U 18666A |
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Inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo.
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| BCC7137 | [bAla8]-Neurokinin A(4-10) |
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NK2 receptor agonist (pD2 = 6.91). Produces bladder contraction and bronchospasm in guinea pigs in vivo.
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| BCC7138 | OLDA |
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Potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC<sub>50</sub> = 36 nM at hVR1) with low affinity for rCB<sub>1</sub> receptors (K<sub>i</sub> = 1.6 <span class='symbol'>μ</span>M). Potently induces VR1-mediated thermal hyperalgesia in rats <em>in vivo</em>.
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| BCC7139 | Mesulergine hydrochloride |
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5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.
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| BCC7140 | 8-CPT-2Me-cAMP, sodium salt |
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Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC<sub>50</sub> = 2.2 <span class='symbol'>μ</span>M), but not PKA (EC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Stimulates Epac-mediated Ca<sup>2+</sup>-mediated Ca<sup>2+</sup> release in pancreatic <span class='symbol'>β</span>-cells <em>in vitro</em>.Cell permeable analog also available.
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| BCC7141 | Apamin |
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Prototypical potent and highly selective inhibitor of the small-conductance Ca2+-activated K+-channel (KCa2, SK). Blocks medium after-hyperpolarization in vitro and is brain penetrant and convulsive in vivo.
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| BCC7142 | GR 125487 sulfamate |
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Potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Centrally active following systemic administration in vivo.
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