Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2569 - 2576 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7127 | Rottlerin |
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Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC<sub>50</sub> values are 1.9 and 5 <span class='symbol'>μ</span>M respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
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| BCC7128 | SB 366791 |
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Potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA<sub>2</sub> = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB<sub>1</sub> and CB<sub>2</sub> receptors, voltage-gated Ca<sup>2+</sup> channels and the hyperpolarization-activated current (I<sub>h</sub>). Also available as part of the Vanilloid TRPV1 Receptor.
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| BCC7129 | Remacemide hydrochloride |
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Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na+ channels (IC50 = 161 mM).
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| BCC7130 | DFB |
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Novel allosteric potentiator of the metabotropic glutamate receptor mGlu<sub>5</sub>. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu<sub>5</sub> without any effect at other mGlu subtypes (EC<sub>50</sub> for potentiation = 2 - 5.3 <span class='symbol'>μ</span>M).
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| BCC7131 | Calphostin C |
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Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC<sub>50</sub> = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions <em>in vitro</em> (IC<sub>50</sub> ~ 40 - 60 nM). Also an antagonist of the Tcf/<span class='symbol'>β</span>-catenin complex.
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| BCC7132 | Herbimycin A |
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Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.
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| BCC7133 | MEN 10376 |
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Potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1 (pA2 = 5.66, guinea pig ileum) and NK3 (Ki > 10 mM, guinea pig brain). Active in vivo.
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| BCC7134 | RP 67580 |
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Potent and selective tachykinin NK<sub>1</sub> receptor antagonist (K<sub>i</sub> values are 2.9 nM and > 10 <span class='symbol'>μ</span>M for rat NK<sub>1</sub>, and rat NK<sub>2</sub> and NK<sub>3</sub> receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive <em>in vivo</em>, possibly partly via inhibition of calcium channels.
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