Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4126 | Phlorizin |
| Phlorizin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. Phlorizin may be a novel therapeutic approach for the treatment of diabetic nephrolog, it protects mice from diabetic nephrology. Phlorizin prevents ventricular tachyarrhythmia through the improvement of impulse conduction slowing during ischemia. | |
| BCN4127 | Guaiacin |
| (+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2. (+)-Guaiacin shows potent in vitro activities against the release of beta-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF), with 42.5-75.6% inhibition at 10(-5) M. | |
| BCN4128 | Phloretin |
| Phloretin may potentially be an immunomodulator by impairing the activation and function of DCs, it is effective in preventing estrogen deficiency-induced osteoclastogenic resorption. Phloretin has antimicrobial activity against the Gram negative bacteria Salmonella typhimurium ATCC 13311. It has a wide spectrum of targets including ASK-1-MAPK, Smac, capase. | |
| BCN4129 | Ferulamide |
| 1. Ferulamide derivatives show potent inhibitory activity against arachidonic acid-induced platelet aggregation. | |
| BCN4130 | Isobonducellin |
| 1. Isobonducellin exhibits potent cytotoxic activity in Jurkat and HepG2 cells, while moderate growth inhibition against Colon205 cells. | |
| BCN4131 | 3,9-Dihydroxypterocarpan |
| 1. 3,9-Dihydroxypterocarpan and phaseollidin are all good precursors of the pterocarpan phytoalexin phaseollin. | |
| BCN4133 | Grandifloroside |
| 1. Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it might be developed as a source of potent anti-oxidative and anti-inflammatory agents and therapeutic agent for benign prostatic hypertrophy (BPH). | |
| BCN4135 | Vitexilactone |
| 1. Vitexilactone dramatically induces apoptosis both on tsFT210 and K562 cells at higher concentrations while at lower concentrations it inhibits the cell cycle progression of both tsFT210 and K562 cells at the G0/G1 phase; it is one anticancer component of Vitex trifolia L., which exerts its anti-proliferative effect on cancer cells through inducing apoptosis and inhibiting the cell cycle. 2. Vitexilactone has trypanocidal activity, the minimum lethal concentration against epimastigotes of Trypanosoma cruzi is 66 microM . 3. Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. | |
