Hot Natural Products & Bioactive Compounds

BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.

Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.

Hot Products from BioCrick

Showing 2713 - 2720 of 9359 hot products

BioCrick hot natural products and bioactive compounds
Catalog No.	Product Name
BCC7276	Ro 0437626
Selective P2X<sub>1</sub> purinergic receptor antagonist (IC<sub>50</sub> = 3 <span class='symbol'>μ</span>M) that displays > 30-fold selectivity over P2X<sub>2</sub>, P2X<sub>3</sub> and P2X<sub>2/3</sub> receptors (IC<sub>50</sub> > 100 <span class='symbol'>μ</span>M).
BCC7277	SR 27897
Potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.
BCC7278	Carmoxirole hydrochloride
Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
BCC7279	R 59-022
Diacylglycerol (DAG) kinase inhibitor (IC<sub>50</sub> = 2.8 <span class='symbol'>μ</span>M); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.
BCC7280	Eliprodil
Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC<sub>50</sub> values are 1, > 100 and > 100 <span class='symbol'>μ</span>M respectively). Also <span class='symbol'>σ</span><sub>1</sub> ligand (K<sub>i</sub> = 0.013 <span class='symbol'>μ</span>M). Antagonizes neuronal voltage-gated Ca<sup>2+</sup> channels and selectively inhibits the rapid component of the delayed rectifier K<sup>+</sup> current (I<sub>Kr</sub>). Neuroprotective.
BCC7281	3-MATIDA
Potent metabotropic glutamate mGlu<sub>1</sub> receptor antagonist (IC<sub>50</sub> = 6.3 <span class='symbol'>μ</span>M at rat mGlu<sub>1a</sub>). Displays ≥ 40-fold selectivity over other receptors: mGlu<sub>5</sub>, mGlu<sub>2</sub>, mGlu<sub>4a</sub> (IC<sub>50</sub> > 300 <span class='symbol'>μ</span>M), NMDA and AMPA (IC<sub>50</sub> = 250 <span class='symbol'>μ</span>M). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures <em>in vitro</em>. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration <em>in vivo</em>.
BCC7282	L-755,507
Potent <span class='symbol'>β</span><sub>3</sub>-adrenergic receptor partial agonist > 1000-fold selective over <span class='symbol'>β</span><sub>1</sub>- and <span class='symbol'>β</span><sub>2</sub>-adrenoceptors (EC<sub>50</sub> values are 0.43, 580 and > 10000 nM for activation of cloned human <span class='symbol'>β</span><sub>3</sub>-, <span class='symbol'>β</span><sub>1</sub>- and <span class='symbol'>β</span><sub>2</sub>-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes <em>in vitro</em> (EC<sub>50</sub> = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs).
BCC7283	CGP 71683 hydrochloride
Extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.