Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2697 - 2704 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7260 | RS 102895 hydrochloride |
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CCR2-selective chemokine receptor antagonist (IC<sub>50</sub> values are 0.36 and 17.8 <span class='symbol'>μ</span>M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC<sub>50</sub> values of 32 nM and 1.7 <span class='symbol'>μ</span>M respectively. Also inhibits <span class='symbol'>α</span><sub>1A</sub>, <span class='symbol'>α</span><sub>1D</sub> and 5-HT<sub>1A</sub> receptors.
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| BCC7261 | Ionomycin free acid |
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Calcium ionophore; more specific than A23187.
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| BCC7262 | PNU 37883 hydrochloride |
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Novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.
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| BCC7263 | DAU 5884 hydrochloride |
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Selective muscarinic M3 receptor antagonist. In bovine tracheal smooth muscle, inhibits methacholine-dependent effects on cell proliferation and muscle contractility.
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| BCC7264 | α-Bungarotoxin |
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Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for <span class='symbol'>α</span>7 receptors over <span class='symbol'>α</span>3<span class='symbol'>β</span>4 receptors (IC<sub>50</sub> values are 1.6 nM and > 3 <span class='symbol'>μ</span>M respectively).
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| BCC7265 | Paroxetine maleate |
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Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K<sub>i</sub> = 0.05 nM). K<sub>i</sub> values are 1.1, 350 and 1100 nM for inhibition of [<sup>3</sup>H]-5-HT, [<sup>3</sup>H]-l-NA and [<sup>3</sup>H]-DA uptake respectively. Displays minimal affinity for <span class='symbol'>α</span><sub>1</sub>-, <span class='symbol'>α</span><sub>2</sub>- or <span class='symbol'>β</span>-adrenoceptors, 5-HT<sub>2A</sub>, 5-HT<sub>1A</sub>, D<sub>2</sub> or H<sub>1</sub> receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K<sub>i</sub> = 42 nM). Antidepressant and anxiolytic <em>in vivo</em>.
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| BCC7266 | SCS |
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Potent and selective partial inhibitor of <span class='symbol'>β</span>1-containing GABA<sub>A</sub> receptors (IC<sub>50</sub> values are 4.5, 5.3 and 7.9 nM at <span class='symbol'>α</span>2<span class='symbol'>β</span>1<span class='symbol'>γ</span>1<span class='symbol'>θ</span>, <span class='symbol'>α</span>2<span class='symbol'>β</span>1<span class='symbol'>γ</span>1 and <span class='symbol'>α</span>2<span class='symbol'>β</span>1<span class='symbol'>γ</span>2s GABA<sub>A</sub> receptors respectively). May bind allosterically to a novel site on GABA<sub>A</sub> receptor.
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| BCC7267 | (±)-McN 5652 |
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Potent, high affinity serotonin re-uptake inhibitor; selective in vivo. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer.
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