Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4327 | Ursolic acid |
| Ursolic acid is a potential PPARγagonist, which has anti-tumor, chemopreventive, hepatoprotective, anti-inflammatory, antioxidant, antidepressant-like, antimicrobial activities, and anti-asthmatic effects. Ursolic acid also has antihyperlipidemic, hypoglycemic and direct cardiac effect, its antihypertensive effect is attributed to its potent diuretic-natriuretic-saluretic activity. Ursolic acid regulates NF-κB, VEGF, COX-2, Nrf2, ARE, IL-5, IL-13, IL-17and MAPK signaling pathways. | |
| BCN1358 | 1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone |
| 1. 1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans. | |
| BCN4328 | Dehydrocrebanine |
| 1. Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. 2. Dehydrocrebanine shows potent antimalarial activity with an IC50 value of 70 ng/ml. | |
| BCN4329 | Longikaurin E |
| 1. Longikaurin E induces apoptosis of pancreatic cancer cells via ROS generation to modulate the p38 and PI3K/AKT pathways and could be a promising anti-pancreatic agent. | |
| BCN4330 | 19-Hydroxybaccatin III |
| 1. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol are new antitumor taxanes from Taxus wallichiana. | |
| BCN4331 | N-trans-Feruloyl-3-methoxytyramine |
| 1. N-trans-Feruloyl-3-methoxytyramine shows significantly DPPH radical scavenging activities. | |
| BCN4332 | Excisanin B |
| 1. Excisanin B shows inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells. | |
| BCN4333 | 9-Oxo-10,11-dehydroageraphorone |
| 1. 9-Oxo-10,11-dehydroageraphorone has acaricidal activity. 2. 9-Oxo-10,11-dehydroageraphorone induces hepatotoxicity and cholestasis in rats. 3. 9-Oxo-10,11-dehydroageraphorone effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M phase. | |
