Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2777 - 2784 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7340 | Gavestinel |
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Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo.
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| BCC7341 | Dihydro-β-erythroidine hydrobromide |
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Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal <span class='symbol'>α</span>4 receptor subunit (IC<sub>50</sub> values are 0.19 and 0.37 <span class='symbol'>μ</span>M for <span class='symbol'>α</span>4<span class='symbol'>β</span>4 and <span class='symbol'>α</span>4<span class='symbol'>β</span>2 receptors respectively). Antagonizes behavioral effects of nicotine <em>in vivo</em>.
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| BCC7343 | Bryostatin 1 |
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Protein kinase C (PKC) activator that binds with high affinity (K<sub>i</sub> = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an <em>in vivo</em> model of fragile X syndrome.
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| BCC7344 | AMN 082 dihydrochloride |
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The first selective mGlu<sub>7</sub> agonist. Potently inhibits cAMP accumulation and stimulates GTP<span class='symbol'>γ</span>S binding in recombinant cells and on membranes expressing mGlu<sub>7</sub> (EC<sub>50</sub> = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 <span class='symbol'>μ</span>M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.
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| BCC7345 | Fenobam |
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Potent and selective non-competitive mGlu5 antagonist that displays inverse agonist properties; blocks mGlu5 constitutive activity in vitro (IC50 = 87 nM). Acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo; also exhibits analgesic properties.
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| BCC7346 | LY 320135 |
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Potent CB<sub>1</sub> receptor antagonist/inverse agonist (K<sub>i</sub> = 141 nM) with greater than 70-fold selectivity over CB<sub>2</sub> receptors (K<sub>i</sub> > 10 <span class='symbol'>μ</span>M). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT<sub>2</sub> (K<sub>i</sub> = 6.4 <span class='symbol'>μ</span>M) and muscarinic receptors (K<sub>i</sub> = 2.1 <span class='symbol'>μ</span>M).
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| BCC7347 | LY 456236 hydrochloride |
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Selective mGlu<sub>1</sub> receptor antagonist (IC<sub>50</sub> values are 143 nM and > 10 <span class='symbol'>μ</span>M for mGlu<sub>1</sub> and mGlu<sub>5</sub> receptors respectively). Reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED<sub>50</sub> values of 28 and 16.3 mg/kg respectively.
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| BCC7348 | JTE 013 |
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Sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P<sub>2</sub> (EDG-5). Inhibits S1P binding to human S1P<sub>2</sub> receptors with an IC<sub>50</sub> value of 17.6 nM. At concentrations up to 10 <span class='symbol'>μ</span>M, displays 4.2% inhibition of S1P<sub>3</sub> and does not antagonize S1P<sub>1</sub>. Enhances S1P-induced angiogenesis <em>in vivo</em>.
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