Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2785 - 2792 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7349 | SDZ NKT 343 |
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Highly selective human tachykinin NK1 receptor antagonist (IC50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK2 and NK3 receptors. Potently antagonizes SP-induced Ca2+ efflux in vitro and inhibits mechanical hyperalgesia in vivo.
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| BCC7350 | SNAP 5089 |
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Subtype-selective <span class='symbol'>α</span><sub>1A</sub>-adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (K<sub>i</sub>values are 0.35, 220, 370, 540, 800 and 1200 nM for <span class='symbol'>α</span><sub>1A</sub>, <span class='symbol'>α</span><sub>1B</sub>, <span class='symbol'>α</span><sub>2C</sub>, <span class='symbol'>α</span><sub>1D</sub>, <span class='symbol'>α</span><sub>2B</sub> and <span class='symbol'>α</span><sub>2A</sub> subtypes respectively and 540 nM for L-type Ca<sup>2+</sup> channels). Inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues.
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| BCC7351 | Ro 90-7501 |
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Inhibitor of amyloid <span class='symbol'>β</span>42 (A<span class='symbol'>β</span>42) fibril assembly; reduces A<span class='symbol'>β</span>42-induced toxicity (EC<sub>50</sub> = 2 <span class='symbol'>μ</span>M).
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| BCC7352 | Conessine |
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Potent and selective histamine H<sub>3</sub> receptor antagonist (pK<sub>i</sub> values are 7.61 and 8.27 at rat and human H<sub>3</sub> receptors respectively). A steroidal alkaloid that displays <em>in vitro</em> antiplasmodial activity (IC<sub>50</sub> = 1.04 <span class='symbol'>μ</span>M). Also has high affinity for <span class='symbol'>α</span><sub>2C</sub> adrenoceptors (pK<sub>i</sub> = 7.98).
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| BCC7353 | L-371,257 |
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Potent, high affinity human oxytocin (OT) receptor antagonist (Ki = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V1a and V2. Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Decreases length of U-87MG cell projections induced by retinoic acid (Cat.No.0695). Orally active.
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| BCC7354 | A-71623 |
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Potent CCK<sub>1</sub> agonist (IC<sub>50</sub> = 3.7 nM) with 1200-fold selectivity over the CCK<sub>2</sub> receptor. Suppresses food intake following central or peripheral administration.
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| BCC7355 | BIBO 3304 trifluoroacetate |
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High affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.
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| BCC7356 | BIBU 1361 dihydrochloride |
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Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC<sub>50</sub> = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC<sub>50</sub> = 290 nM) and is selective over a range of other related tyrosine kinases (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.
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