Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2801 - 2808 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7365 | Desmethyl-YM 298198 |
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Derivative of the mGlu<sub>1</sub>-selective antagonist YM 298198.
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| BCC7366 | YM 298198 hydrochloride |
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Non-competitive antagonist with high affinity and selectivity for mGlu<sub>1</sub> receptors (K<sub>i</sub> = 19 nM); inactive at other mGlu receptor subtypes (mGlu<sub>2-7</sub>), ionotropic receptors and glutamate transporters (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC<sub>50</sub> values are 16 nM and 6.3 <span class='symbol'>μ</span>M respectively), and is orally active <em>in vivo</em>, demonstrating an antinociceptive effect in hyperalgesic mice. Desmethyl derivative also available.
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| BCC7367 | NF 157 |
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Purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.
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| BCC7368 | LY 379268 |
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Highly selective group II mGlu receptor agonist (EC<sub>50</sub> values are 2.69 and 4.48 nM for hmGlu<sub>2</sub> and hmGlu<sub>3</sub> respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death <em>in vitro</em> and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available .
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| BCC7369 | Co 101244 hydrochloride |
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Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC<sub>50</sub> values are 0.043, > 100 and > 100 <span class='symbol'>μ</span>M for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects <em>in vivo</em> and <em>in vitro</em>.
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| BCC7370 | Arcyriaflavin A |
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Potent inhibitor of cdk4/cyclin D1 (IC<sub>50</sub> = 59 nM). Also active against CaM kinase II (IC<sub>50</sub> = 25 nM) but displays selectivity over several other kinases <em>in vitro</em> (IC<sub>50</sub> values for inhibition of PKA and PKC are > 2 and > 100 <span class='symbol'>μ</span>M respectively). Inhibits human cytomegalovirus (HCMV) replication <em>in vitro</em> (IC<sub>50</sub> = 200 nM).
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| BCC7371 | Lazabemide hydrochloride |
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Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC<sub>50</sub> values are 0.03 and > 100 <span class='symbol'>μ</span>M for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC<sub>50</sub> values are 86, 123 and > 500 <span class='symbol'>μ</span>M for noradrenalin, serotonin and dopamine uptake respectively).
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| BCC7372 | SCH 442416 |
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Selective adenosine A<sub>2A</sub> receptor antagonist; binds to human and rat A<sub>2A</sub> receptors with high affinity (K<sub>i</sub> values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA<sub>2A</sub> over hA<sub>1</sub> <em>in vitro</em> with minimal affinity for hA<sub>2B</sub> and hA<sub>3</sub> receptors (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Blocks the cytoprotective effect of A<sub>2A</sub> agonist CGS-21680.
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