Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2705 - 2712 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7268 | nTZDpa |
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Potent, selective non-thiazolidinedione PPAR<span class='symbol'>γ</span> partial agonist (EC<sub>50</sub> = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC<sub>50</sub> ~ 285 nM). Displays no activity at PPAR<span class='symbol'>α</span> or PPAR<span class='symbol'>δ</span> receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR<span class='symbol'>γ</span> agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice <em>in vivo</em>.
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| BCC7269 | NSC 625987 |
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Cyclin-dependent kinase (cdk) 4 inhibitor (IC<sub>50</sub> = 0.2 <span class='symbol'>μ</span>M at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC<sub>50</sub> > 100 <span class='symbol'>μ</span>M for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
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| BCC7270 | NTNCB hydrochloride |
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Selective, non-peptide competitive NPY Y<sub>5</sub> antagonist. K<sub>i</sub> values are 8.0 and 16032 nM at human recombinant Y<sub>5</sub> and Y<sub>1</sub> receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D<sub>2</sub> and <span class='symbol'>α</span><sub>2C</sub> receptors (K<sub>i</sub> values are 63 and 100 nM respectively).
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| BCC7271 | WAY 629 hydrochloride |
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Selective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats.
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| BCC7272 | ZK 164015 |
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Potent estrogen receptor silent antagonist. Inhibits 17<span class='symbol'>β</span>-estradiol stimulation of luciferase activity (IC<sub>50</sub> = 0.025 <span class='symbol'>μ</span>M); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells <em>in vitro</em> (IC<sub>50</sub> ~ 1 nM).
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| BCC7273 | SN-6 |
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Selective Na<sup>+</sup>/Ca<sup>2+</sup>-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC<sub>50</sub> values are 2.9, 16 and 8.6 <span class='symbol'>μ</span>M for inhibition of intracellular Na+-dependent <sup>45</sup>Ca<sup>2+</sup> uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC<sub>50</sub> = 18 <span class='symbol'>μ</span>M) but minimal activity against NCKX2 and various receptors and ion channels (IC<sub>50</sub> > 30 <span class='symbol'>μ</span>M). Preferentially blocks Ca<sup>2+</sup> influx mode and is more selective for NCX isoforms than KB-R7943. Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC<sub>50</sub> = 0.63 <span class='symbol'>μ</span>M).
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| BCC7274 | CMPD-1 |
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Non-ATP-competitive, selective inhibitor of p38<span class='symbol'>α</span>-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent K<sub>i</sub> = 330 nM). Does not inhibit p38<span class='symbol'>α</span>-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.
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| BCC7275 | NS 3763 |
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Selective non-competitive kainate receptor antagonist; displays selectivity for GLU<sub>K5</sub> subunit-containing receptors (IC<sub>50</sub> values are 1.6 and > 30 <span class='symbol'>μ</span>M for homomeric GLU<sub>K5</sub> and GLU<sub>K6</sub> receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC<sub>50</sub>> 30 <span class='symbol'>μ</span>M).
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