Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2889 - 2896 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC7453 | Pentylenetetrazole |
|
CNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.
|
|
| BCC7454 | POM 1 |
|
Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y<sub>12</sub> (K<sub>i</sub> values are 2.58, 3.26, > 10 and 28.8 <span class='symbol'>μ</span>M for NTPDase 1, NTPDase 3, P2Y<sub>12</sub> and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.
|
|
| BCC7455 | YM 90K hydrochloride |
|
Selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration.
|
|
| BCC7457 | Cilastatin sodium |
|
Dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a K<sub>i</sub> value of 0.11 <span class='symbol'>μ</span>M. Inhibits metabolism of LTD<sub>4</sub> to LTE<sub>4</sub> and the hydrolysis of <span class='symbol'>β</span>-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
|
|
| BCC7458 | OGT 2115 |
|
Heparanase inhibitor (IC<sub>50</sub> = 0.4 <span class='symbol'>μ</span>M) that displays no major inhibition of human cytochrome P450 isoenzymes (IC<sub>50</sub> > 30 μM). Exhibits antiangiogenic properties <em>in vitro</em> (IC<sub>50</sub> = 1 <span class='symbol'>μ</span>M).
|
|
| BCC7459 | PSB 0474 |
|
Potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.
|
|
| BCC7460 | RWJ 21757 |
|
Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
|
|
| BCC7461 | Zoniporide dihydrochloride |
|
Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.
|
|