Torachrysone 8-O-glucosideCAS# 64032-49-1 |
Quality Control & MSDS
3D structure
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| Cas No. | 64032-49-1 | SDF | Download SDF |
| PubChem ID | 11972479 | Appearance | Yellow powder |
| Formula | C20H24O9 | M.Wt | 408.4 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-[1-hydroxy-6-methoxy-3-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynaphthalen-2-yl]ethanone | ||
| SMILES | CC1=C(C(=C2C(=C1)C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)OC)O)C(=O)C | ||
| Standard InChIKey | GHKWPHRULCFTBB-CZNQJBLBSA-N | ||
| Standard InChI | InChI=1S/C20H24O9/c1-8-4-10-5-11(27-3)6-12(15(10)17(24)14(8)9(2)22)28-20-19(26)18(25)16(23)13(7-21)29-20/h4-6,13,16,18-21,23-26H,7H2,1-3H3/t13-,16-,18+,19-,20-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Torachryson-8-O-glucoside shows alpha-glucosidase inhibitory activities, it may be used for the management of type 2 diabetes. |
| Targets | Antifection |
Torachrysone 8-O-glucoside Dilution Calculator
Torachrysone 8-O-glucoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4486 mL | 12.2429 mL | 24.4858 mL | 48.9716 mL | 61.2145 mL |
| 5 mM | 0.4897 mL | 2.4486 mL | 4.8972 mL | 9.7943 mL | 12.2429 mL |
| 10 mM | 0.2449 mL | 1.2243 mL | 2.4486 mL | 4.8972 mL | 6.1214 mL |
| 50 mM | 0.049 mL | 0.2449 mL | 0.4897 mL | 0.9794 mL | 1.2243 mL |
| 100 mM | 0.0245 mL | 0.1224 mL | 0.2449 mL | 0.4897 mL | 0.6121 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The screening of potential α-glucosidase inhibitors from the Polygonum multiflorum extract using ultrafiltration combined with liquid chromatography-tandem mass spectrometry
Anal. Methods-UK. 2014, 6(10):3353-9.
α-Glucosidase inhibitors have been used for the management of type 2 diabetes (T2DM) for a long time. The natural α-glucosidase inhibitors from Chinese herbal medicine have become an attractive therapeutic approach for treating T2DM due to their low toxicity. In this study, a new kind of in vitro α-glucosidase inhibition assay based on using maltose as the substrate was developed, and this new established method was used to determine the α-glucosidase inhibitory activities of Polygonum multiflorum and four anthraquinone compounds. As a result, Polygonum multiflorum showed 50% α-glucosidase inhibition at the concentration of 0.0032 mg mL−1 and four anthraquinone compounds including emodin, aloe-emodin, physcion and rhein showed strong α-glucosidase inhibitory activities with IC50 values ranging from 4.12 μM to 5.68 μM, respectively. Moreover, the centrifugal ultrafiltration with LC-ESI-MSn was used to screen and identify active α-glucosidase inhibitors from Polygonum multiflorum extract and nine small-molecule active compounds were successfully identified as potential α-glucosidase inhibitors. Five compounds belonged to the anthraquinone group including emodin, physcion, aloe-emodin, rhein and physcion-8-O-glucoside, while the others were catechin, resveratrol, 2,3,5,4′-tetrahydroxystilbene-2-O-glucoside and Torachrysone 8-O-glucoside.
