Tetracycline HydrochlorideCAS# 64-75-5 |
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| Cas No. | 64-75-5 | SDF | Download SDF |
| PubChem ID | 54704426 | Appearance | Powder |
| Formula | C22H25ClN2O8 | M.Wt | 480.90 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 62.5 mg/mL (129.96 mM; Need ultrasonic) H2O : 50 mg/mL (103.97 mM; Need ultrasonic) | ||
| Chemical Name | Tefilin | ||
| SMILES | [Cl-].CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)c4c(O)cccc4[C@@]3(C)O)C(=O)[C@]2(O)C(=O)C(=C(N)/O)C1=O.[H+] | ||
| Standard InChIKey | DYQBMRZOOXYHIM-NCKOGSTASA-N | ||
| Standard InChI | InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25-26,30-32H,7,23H2,1-3H3;1H/b20-14-;/t9-,10-,15-,21+,22-;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Tetracycline hydrochloride is a broad-spectrum antibiotic used to treat a wide range of infections.In Vitro:Tetracyclines are broad-spectrum agents, exhibiting activity against a wide range of gram-positive and gram-negative bacteria, atypical organisms such as chlamydiae, mycoplasmas, and rickettsiae, and protozoan parasites. Tetracyclines inhibit bacterial protein synthesis by preventing the association of aminoacyl-tRNA with the bacterial ribosome. Tetracyclines traverse the outer membrane of gram-negative enteric bacteria through the OmpF and OmpC porin channels, as positively charged cation (probably magnesium)-tetracycline coordination complexes [1].In Vivo:The tetracyclines have applications for the treatment of infections in poultry, cattle, sheep, and swine. In some cases, e.g., for therapeutic treatment of large numbers of poultry reared on commercial farms, the antibiotics are added directly to feed or water or can be administered in aerosols. Tetracyclines could be used as growth promotion or growth enhancement. Tetracyclines are used in aquaculture to control infections in salmon, catfish, and lobsters[2]. References: | |||||
Tetracycline Hydrochloride Dilution Calculator
Tetracycline Hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0794 mL | 10.3972 mL | 20.7943 mL | 41.5887 mL | 51.9859 mL |
| 5 mM | 0.4159 mL | 2.0794 mL | 4.1589 mL | 8.3177 mL | 10.3972 mL |
| 10 mM | 0.2079 mL | 1.0397 mL | 2.0794 mL | 4.1589 mL | 5.1986 mL |
| 50 mM | 0.0416 mL | 0.2079 mL | 0.4159 mL | 0.8318 mL | 1.0397 mL |
| 100 mM | 0.0208 mL | 0.104 mL | 0.2079 mL | 0.4159 mL | 0.5199 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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antibiotic toxic store at -20°C, warm to room temperature before use soluble in water at 10mg/ml soluble in ethanol at 5mg/ml
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CeO2 /Bi2 WO6 Heterostructured Microsphere with Excellent Visible-light-driven Photocatalytic Performance for Degradation of Tetracycline Hydrochloride.[Pubmed:28261814]
Photochem Photobiol. 2017 Oct;93(5):1154-1164.
CeO2 /Bi2 WO6 heterostructured microsphere with excellent and stable photocatalytic activity for degradation tetracyclines was successfully synthesized via a facile solvothermal route. The photocatalytic experiments indicated that CeO2 /Bi2 WO6 heterostructured microspheres exhibited enhanced photocatalytic activity compared to pure Bi2 WO6 in both the degradation of Tetracycline Hydrochloride (TCH) and rhodamine B (RhB) under visible-light irradiation. The 1CeO2 /2Bi2 WO6 exhibited the best photocatalytic activity for degradation of TCH, reaching 91% after 60 min reaction. The results suggested that the particular morphological conformation of the microspheres resulted in smaller size and more uniform morphology so as to increase the specific surface area. Meanwhile, the heterojunction was formed by coupling CeO2 and Bi2 WO6 in the as-prepared microspheres, so that the separation efficiency of photogenerated electrons and holes was dramatically improved and the lifetimes of charge carriers were prolonged. Hence, introduction of CeO2 could significantly enhance the photocatalytic activity of CeO2 /Bi2 WO6 heterostructured microspheres and facilitate the degradation of TCH. This work provided not only a principle method to synthesize CeO2 /Bi2 WO6 with the excellent photocatalytic performance for actual produce, but also a excellent property of the photocatalyst for potential application in photocatalytic treatment of tetracyclines wastewater from pharmaceutical factory.
Novel Bi2 WO6 -coupled Fe3 O4 Magnetic Photocatalysts: Preparation, Characterization and Photodegradation of Tetracycline Hydrochloride.[Pubmed:28199743]
Photochem Photobiol. 2017 Jul;93(4):1034-1042.
Novel Bi2 WO6 -coupled Fe3 O4 magnetic photocatalysts with excellent and stable photocatalytic activity for degrading Tetracycline Hydrochloride and RhB were successfully synthesized via a facile solvothermal route. Through the characterization of the as-prepared magnetic photocatalysts by X-ray diffractometry, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, UV-Vis diffuse reflectance spectra, it was found that the as-prepared magnetic photocatalysts were synthesized by the coupling of Bi2 WO6 and Fe3 O4 , and introduction of appropriated Fe3 O4 can improve nanospheres morphology and visible-light response. Among them, BFe2 (0.16% Fe3 O4 ) exhibited the best photocatalytic activity for degradation of Tetracycline Hydrochloride (TCH), reaching 81.53% after 90 min. Meanwhile, the as-prepared magnetic photocatalysts showed great separation and recycle property. Moreover, the results of electrochemical impedance spectroscopy demonstrated that the well conductivity of Fe3 O4 can promote photogenerated charge carriers transfer and inhibit recombination of electron-hole pairs, so that Bi2 WO6 /Fe3 O4 exhibited enhanced photocatalytic activity on degradation of TCH and RhB. Hence, this work provides a principle method to synthesize Bi2 WO6 /Fe3 O4 with excellent photocatalytic performance for actual application, in addition, it showed that introduction of Fe3 O4 not only can provide magnetism, but also can enhance photocatalytic activity of Bi2 WO6 /Fe3 O4 magnetic photocatalysts.
Rapid analysis of tetracycline hydrochloride solution by attenuated total reflection terahertz time-domain spectroscopy.[Pubmed:28159265]
Food Chem. 2017 Jun 1;224:262-269.
Despite numerous methods for the detection of antibiotic residues, they are usually destructive and require tedious pre-treatment. Terahertz time-domain spectroscopy (THz-TDS) is an emerging technology that has advantages for analyzing chemical and biological compounds since THz waves are very sensitive to the molecular vibrational modes. Here we incorporated attenuated total reflection technique into the THz-TDS and demonstrated that this technology (ATR THz-TDS) allowed to determine the complex refractive indices of Tetracycline Hydrochloride (TCH) solutions with high accuracy and could be used to predict their concentrations. Our results from the simple linear regression models indicated that the complex refractive index exhibited a monotonic decrease with an increase in the TCH concentration. This study will provide new knowledge about the concentration determination of a liquid sample that couldn't be elucidated with the conventional THz-TDS technologies.
Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing.[Pubmed:27770893]
Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 1):287-295.
An antibacterial and biodegradable composite hydrogel dressing integrated with microspheres is developed for drug delivery and wound healing. The mechanism of gelation is attributed to the Schiff-base reaction between aldehyde and amino groups of oxidized alginate (OAlg) and carboxymethyl chitosan (CMCS). To enhance antibacterial and mechanical properties, Tetracycline Hydrochloride (TH) loaded gelatin microspheres (GMs) were fabricated by an emulsion cross-linking method, followed by integrating into the OAlg-CMCS hydrogel to produce a composite gel dressing. In vitro gelation time, swelling, degradation, compressive modulus and rheological properties of the gel dressing were investigated as the function of microsphere ratios. With increasing ratios of microspheres from 10 to 40mg/mL, the composite dressing manifested shorter gelation time and lower swelling ratios, as well as higher mechanical strength. Comparing to other formulations, the gel dressing with 30mg/mL microspheres showed more suitable stabilities and mechanical properties for wound healing. Also, in vitro drug release results showed that the loaded TH could be sustained release from the composite gel dressing by contrast with pure hydrogels and microspheres. Furthermore, powerful bacteria growth inhibition effects against Escherichia coli and Staphylococcus aureus suggested that the composite gel dressing, especially the one with 30mg/mL GMs containing TH, has a promising future in treatment of bacterial infection.
