Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2497 - 2504 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7055 | Chromanol 293B |
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Blocker of the slow delayed rectifier K<sup>+</sup> current (I<sub>Ks</sub>) (IC<sub>50</sub> = 1-10 <span class='symbol'>μ</span>M). Also blocks the CFTR chloride current (I<sub>CFTR</sub>) (IC<sub>50</sub> = 19 <span class='symbol'>μ</span>M). (-)-[3<em>R</em>,4<em>S</em>]-Chromanol 293B also available.
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| BCC7056 | NAS-181 |
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Potent, selective antagonist at the rat 5-HT<sub>1B</sub> receptor (K<sub>i</sub> = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance <em>in vivo</em>. Increases subthalamic nucleus-triggered complex EPSCs and burst firing in SNr GABA neurons
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| BCC7057 | 1400W dihydrochloride |
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Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (K<sub>d</sub> = 7 nM). Selective over nNOS and eNOS (K<sub>i</sub> values are 2 and 50 <span class='symbol'>μ</span>M respectively). Cell-permeable and active <em>in vivo</em>.
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| BCC7058 | D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt |
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Phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Potent inhibitor of Ins (1,4,5)P3 5-phosphatase (IC50 ~150 nM); facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P3 receptors.
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| BCC7059 | MAFP |
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Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC50 = 2.5 nM). Also binds irreversibly to CB1 receptors (IC50 = 20 nM).
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| BCC7060 | DCEBIO |
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Stimulates Cl<sup>-</sup> secretion via the activation of hK<sub>Ca</sub>3.1 (IK1) potassium channels and an apical Cl<sup>-</sup> conductance carried by the CFTR channel. More potent than its analog 1-EBIO.
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| BCC7061 | (S)-(+)-Dimethindene maleate |
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Enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.
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| BCC7062 | PPT |
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Potent, subtype-selective estrogen receptor agonist (EC<sub>50</sub> ~ 200 pM); displays 410-fold selectivity for ER<span class='symbol'>α</span> over ER<span class='symbol'>β</span>. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration <em>in vivo</em>.
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