Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN6890 | Dihydroactinidiolide |
| 1. Dihydroactinidiolide, a high light-induced β-carotene derivative that can regulate gene expression and photoacclimation in Arabidopsis. 2. Dihydroactinidiolide has shown to be a potent phytotoxin at low concentration. 3. Dihydroactinidiolide may have interesting potential anticancer activity. | |
| BCN6891 | 2',6'-Dihydroxy-4'-methoxyacetophenone |
| 1. 2',6'-Dihydroxy-4'-methoxyacetophenone is a phytoalexin after fungal inoculation with Botrytis cinerea or UV light irradiation, it has spore germination inhibition on Botrytis cinerea and Phomopsis perniciosa, with ED50 values of 45 and 410 uM, respectively. 2. 2',6'-Dihydroxy-4'-methoxyacetophenone exhibits significant antifungal activities. | |
| BCN6893 | Lupeol acetate |
| 1. Lupeol acetate has anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone. 2. Lupeol acetate shows antifertility activity in male albino rats. 3. Lupeol acetate can significantly improve the symptoms of RA by down-regulating expressions of inflammatory cytokines and osteoclastogenesis. 4. Lupeol acetate possesses antinociceptive aactivities in vivo and in vitro. | |
| BCN6894 | Nepodin |
| 1. Nepodin has anti-inflammatory activity, it shows significant cyclooxygenase (COX) inhibitory activity. 2. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin. 3. Nepodin has Antimalarial activity. 4. Nepodin shows moderate toxicity against Flavobacterium columnare , Edwardsiella ictaluri , and Streptococcus iniae. | |
| BCN6895 | Prerubialatin |
| 1. Prerubialatin is a precursor of rubialatins A and B. | |
| BCN6897 | Dehydroleucodine |
| 1. Dehydroleucodine induces a TP73-dependent transcriptional regulation of multiple cell death target genes in human glioblastoma cells. 2. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. 3. Dehydroleucodine shows embryotoxicity. 4. Dehydroleucodine has gastric cytoprotective activity, it also inhibits the proliferation of vascular smooth muscle cells. 5. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulating the PPARγ expression, which is known to play a pivotal role during adipogenesis. 6. Dehydroleucodine has moderate anti-microbial activity against taphylococcus aureus and Staphylococcus epidermidis strains. 7. Dehydroleucodine has antidiarrheal activity. 8. Dehydroleucodine has anti-inflammatory activity, which may be attributed to interference with multiple targets on the level of transcription factors, such as NF-kappaB, and cytokines. | |
| BCN6898 | Hastatoside |
| Hastatoside and verbenalin are major sleep-promoting components of V. officinalis. Hastatoside has anti-inflammatory activity. | |
| BCN6899 | Anatabine |
| 1. Anatabine can suppress in a dose-dependent manner macrophage production of inducible nitric oxide synthase and cyclooxygenase 2, and ameliorate disease in a model of autoimmune thyroiditis. 2. Anatabine inhibits BACE-1 transcription and reduces BACE-1 protein levels in human neuronal like SHSY-5Y cells suggesting that the Aβ lowering properties of anatabine are mediated via a regulation of BACE-1 expression. 3. Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation. | |
