Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2417 - 2424 of 9359 hot products
| Catalog No. | Product Name |
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| BCC6974 | IDRA 21 |
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Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide.
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| BCC6975 | (RS)-PPG |
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A potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu<sub>8</sub>; anticonvulsant and neuroprotective <em>in vivo</em>. Also available as part of the Group III mGlu Receptor.
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| BCC6976 | SB 224289 hydrochloride |
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Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.
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| BCC6977 | DMPQ dihydrochloride |
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A potent and selective inhibitor of human vascular <span class='symbol'>β</span>-type platelet derived growth factor receptor tyrosine kinase (PDGFR<span class='symbol'>β</span>) (IC<sub>50</sub> = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
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| BCC6978 | 2-APB |
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A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP<sub>3</sub>) receptor antagonist (IC<sub>50</sub> = 42 <span class='symbol'>μ</span>M). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 <span class='symbol'>μ</span>M) and inhibits it at higher concentrations (up to 50 <span class='symbol'>μ</span>M). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.
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| BCC6979 | TCPOBOP |
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Agonist of the constitutive androstane receptor (CAR) (EC<sub>50</sub> = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.
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| BCC6980 | A23187, free acid |
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Calcium ionophore that induces Ca<sup>2+</sup>-dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) <em>in vitro</em> and <em>in vivo</em>. Can be used to induce autophagy in mammalian cells.
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| BCC6981 | Cyclopiazonic acid |
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Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase.
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