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Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN6578	Piperenone
1. Piperenone is an insect antifeeding substance. 2. Piperenone has anti-platelet-activating factor(PAF) activities, it is a PAF-acether antagonist.
BCN6579	Xanthoxyletin
1. Xanthoxyletin shows cytotoxic activity, it can inhibit the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. 2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis through mitochondrial dysfunction, and cell cycle arrest at S phase in a dose-dependent manner, it also can increase the production of reactive oxygen species, suggest that xanthoxyletin may be promising anticancer agent. 3. Xanthoxyletin shows anti-inflammatory activities, it shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2 . 4. Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties.
BCN6582	Gopherenediol
1. Gopherenediol shows weak antifeedant activity.
BCN6583	Mesuol
1. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway. 2. Mesuol has immunomodulatory activity, it can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. 3. Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical.
BCN6585	1-Methyl-2-nonylquinolin-4(1H)-one
1. 1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.
BCN6591	1-Methyl-2-undecylquinolin-4(1H)-one
1. 1-Methyl-2-undecyl-4(1H)-quinolone(1-Methyl-2-undecylquinolin-4(1H)-one) shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity. 2. 1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 3. 1-Methyl-2-undecyl-4(1H)-quinolone can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification by inhibiting phosphate cotransporter (PiT-1) gene expression. 4. 1-Methyl-2-undecyl-4(1H)-quinolone shows moderate antiangiogenic activity against human tumor cells.
BCN6602	Wallichinine
1. Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). 2. Wallichinine can significantly potentiate the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR), suggests that wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products.
BCN6607	ent-16alpha,17-Dihydroxyatisan-3-one
1. ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymphoma cells.