Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN6566 | Puerol A |
| 1. Puerol A exhibits potent inhibitory effects on aldose reductase with IC50 values of 6.4 uM. 2. dl-Puerol A has antioxdiant activity, it shows inhibitory effects on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro. | |
| BCN6567 | Cycloshizukaol A |
| 1.Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 0.9 microM. | |
| BCN6569 | 1-Hydroxy-2,3,5-trimethoxyxanthone |
| 1. 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. 2. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells, it exhibits significant inhibition of osteoclast differentiation even at a low concentration (0.01 ug/mL) in a dose-dependent manner, and it can significantly reduce the pit formation on the dentine slice compared with the control group. 3. HM-1 can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IκB-α protein expression and the suppressing of inducible nitric oxide synthase and cyclooxygenase-Ⅱ protein expression. | |
| BCN6571 | Borapetoside E |
| 1.Borapetoside E has anti-hyperglycemic activity, it can significantly reduce serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice. | |
| BCN6573 | 6-Deoxyjacareubin |
| 1. 6-Deoxyjacareubin, 1,5-dihydroxyxanthone, and 5-hydroxy-1-methoxyxanthoneis are antifungal against Cladosporium cucumerinum, while they show differing degrees of inhibition of monoamine oxidase A and B. 2. 6-Deoxyjacareubin shows strong platelet activating factor (PAF) receptor binding inhibitory effects using rabbit platelets with IC50 values of 29.0 microM, suggests that xanthones can represent a new class of natural PAF receptor antagonists. 3. 6-Deoxyjacareubin possesses significant antioxidant activities. 4. 6-Deoxyjacareubin exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. | |
| BCN6574 | Orsellinic acid |
| 1. Orsellinic acid is a novel benzoquinone ring precursor for antroquinonol and 4-acetylantroquinonol B, it formed from acetyl-coenzyme Q (CoQ) and malonyl-CoA via polyketide pathway. 2. Orsellinic acid can block platelet activating factor (PAF)-mediated neuronal apoptosis without affecting G-protein coupled receptor (PAFR)-mediated neuroprotection, it can effectively attenuate PAFR-independent neuronal apoptosis. | |
| BCN6575 | 5-Hydroxy-1-methoxyxanthone |
| 1. 5-Hydroxy-1-methoxyxanthone, 1,5-dihydroxyxanthone and 6-deoxyjacareubin are all antifungal against Cladosporium cucumerinum, while they show differing degrees of inhibition of monoamine oxidase A and B. | |
| BCN6576 | 8-Epideoxyloganic acid |
| 1. 8-Epideoxyloganic acid (oral) shows weak antinociceptive activity. 2. 8-Epideoxyloganic acid has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activity and/or the radical scavenging effect, and beta2 integrin expression in leucocytes. 3. 8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. | |
