BCN39253-MethylcatecholBotanical source: The Phellinus igniarius(CAS NO.:488-17-5)
BCN6397Furan-3-carboxylic acidBotanical source: The metabolites of Corynebacterium.(CAS NO.:488-93-7)
BCN3725Beta-TocotrienolBotanical source: The stem bark of Garcinia virgata(CAS NO.:490-23-3)
BCN2482GaultherinBotanical source: The herbs of Gaultheria procumbens(CAS NO.:490-67-5)
BCN38252,5-Dihydroxyacetophenone2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways.(CAS NO.:490-78-8)
BCN3408Gentisic acid2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.(CAS NO.:490-79-9)
BCN7177Pyromeconic acidBotanical source: The herbs of Erigeron annuus(CAS NO.:496-63-9)
BCN6307ArbutinArbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.(CAS NO.:497-76-7)
BCN2916AcetovanilloneApocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM.(CAS NO.:498-02-2)
BCN3895beta-ThujaplicinHinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.(CAS NO.:499-44-5)
BCN3565YangoninYangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 ± 0.53 μM and 0.72±0.21 μM, respectively.(CAS NO.:500-62-9)
BCN3564Kawain(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.(CAS NO.:500-64-1)
BCN3515RhapontigeninRhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50 = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively.(CAS NO.:500-65-2)
BCN4629OlivetolOlivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2. Olivetol also inhibits CYP2C19 and CYP2D6 activity, with IC50s of 15.3 μM, 7.21 μM and Kis of 2.71 μM, 2.87 μM, respectively.(CAS NO.:500-66-3)
BCN71983,5-Dimethoxyphenol3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves.(CAS NO.:500-99-2)
BCN3751Cardanol (C15:1)Botanical source: The fruit of Ginkgo biloba(CAS NO.:501-26-8)
BCN5607ResveratrolResveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor.(CAS NO.:501-36-0)
BCN56082-(4-Hydroxyphenyl)ethanolTyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.(CAS NO.:501-94-0)
BCN5609RhododendrolBotanical source: The herbs of Rhododendron pentanthera(CAS NO.:501-96-2)
BCN2950Phloretic acidDesaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.(CAS NO.:501-97-3)
