[Orn8]-Urotensin II

CAS# 479065-85-5

[Orn8]-Urotensin II

2D Structure

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[Orn8]-Urotensin II: 5mg $1300 In Stock
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Quality Control of [Orn8]-Urotensin II

Quality Control & MSDS

3D structure

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[Orn8]-Urotensin II

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Chemical Properties of [Orn8]-Urotensin II

Cas No. 479065-85-5 SDF Download SDF
PubChem ID 90479817 Appearance 479065-85-5 White lyophilised solid
Formula C63H83N13O18S2 M.Wt 1374.54
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
Chemical Name (4S)-4-amino-5-[[(2S,3R)-1-[(2S)-2-[[(2S)-1-[[(4R,7S,10S,13S,16S,19R)-10-(3-aminopropyl)-16-benzyl-4-[[(1S)-1-carboxy-2-methylpropyl]carbamoyl]-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-3-carboxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
SMILES CC(C)C(C(=O)O)NC(=O)C1CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)CCCN)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)NC(=O)C(CC(=O)O)NC(=O)C6CCCN6C(=O)C(C(C)O)NC(=O)C(CCC(=O)O)N
Standard InChIKey KBCMJGTVVAXGOV-QXHQCLFZSA-N
Standard InChI InChI=1S/C63H83N13O18S2/c1-32(2)51(63(93)94)74-60(90)47-31-96-95-30-46(72-58(88)45(28-50(81)82)71-61(91)48-16-10-24-76(48)62(92)52(33(3)77)75-53(83)39(65)21-22-49(79)80)59(89)69-42(25-34-11-5-4-6-12-34)55(85)70-44(27-36-29-66-40-14-8-7-13-38(36)40)57(87)67-41(15-9-23-64)54(84)68-43(56(86)73-47)26-35-17-19-37(78)20-18-35/h4-8,11-14,17-20,29,32-33,39,41-48,51-52,66,77-78H,9-10,15-16,21-28,30-31,64-65H2,1-3H3,(H,67,87)(H,68,84)(H,69,89)(H,70,85)(H,71,91)(H,72,88)(H,73,86)(H,74,90)(H,75,83)(H,79,80)(H,81,82)(H,93,94)/t33-,39+,41+,42+,43+,44+,45+,46+,47+,48+,51+,52+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of [Orn8]-Urotensin II

DescriptionInhibitor of glycogen synthase kinase-3 (GSK-3); derived from FRAT1, the mammalian version of GSK-3-binding protein. Binds to GSK-3, inhibiting its interaction with axin, and also blocks GSK-3-catalyzed phosphorylation of axin and β-catenin. Does not affect GSK-3-mediated phosphorylation of glycogen synthase or eIF2B.

[Orn8]-Urotensin II Dilution Calculator

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[Orn8]-Urotensin II Molarity Calculator

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Preparing Stock Solutions of [Orn8]-Urotensin II

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.7275 mL 3.6376 mL 7.2752 mL 14.5503 mL 18.1879 mL
5 mM 0.1455 mL 0.7275 mL 1.455 mL 2.9101 mL 3.6376 mL
10 mM 0.0728 mL 0.3638 mL 0.7275 mL 1.455 mL 1.8188 mL
50 mM 0.0146 mL 0.0728 mL 0.1455 mL 0.291 mL 0.3638 mL
100 mM 0.0073 mL 0.0364 mL 0.0728 mL 0.1455 mL 0.1819 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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