DyphyllineCAS# 479-18-5 |
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Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 479-18-5 | SDF | Download SDF |
| PubChem ID | 3182 | Appearance | Powder |
| Formula | C10H14N4O4 | M.Wt | 254.24 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 50 mg/mL (196.66 mM) H2O : 20 mg/mL (78.67 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione | ||
| SMILES | CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O | ||
| Standard InChIKey | KSCFJBIXMNOVSH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Dyphylline Dilution Calculator
Dyphylline Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.9333 mL | 19.6665 mL | 39.3329 mL | 78.6658 mL | 98.3323 mL |
| 5 mM | 0.7867 mL | 3.9333 mL | 7.8666 mL | 15.7332 mL | 19.6665 mL |
| 10 mM | 0.3933 mL | 1.9666 mL | 3.9333 mL | 7.8666 mL | 9.8332 mL |
| 50 mM | 0.0787 mL | 0.3933 mL | 0.7867 mL | 1.5733 mL | 1.9666 mL |
| 100 mM | 0.0393 mL | 0.1967 mL | 0.3933 mL | 0.7867 mL | 0.9833 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Dyphylline(Lufyllin, diprophylline) is a xanthine derivative with bronchodilator and vasodilator effects.
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Simultaneous determination of theophylline and dyphylline by micellar electrokinetic chromatography and application in drug formulations.[Pubmed:14522037]
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Oct 5;795(2):329-35.
A simple micellar electrokinetic chromatography is described for well resolution of theophylline, Dyphylline and caffeine. The separation was performed at 25 degrees C using a background electrolyte consisting of 10mM borate buffer at pH 9 and 40 mM sodium dodecyl sulfate (SDS) as running buffer. Under this condition, good separation with high efficiency and short analyses time required is achieved. Several parameters affecting the separation of the drugs were studied, including the pH and concentrations of the borate buffer and sodium dodecyl sulfate. Using caffeine as an internal standard (I.S.), the linear range of the method for the determination of theophylline and Dyphylline was over 0.03-1 micromol ml(-1); the detection limit (signal-to-noise ratio 3; injection 0.3 psi, 3s) was 0.01 and 0.02 micromol ml(-1), respectively.
Kinetic-spectrophotometric determination of theophylline, dyphylline, and proxyphylline by use of partial least-squares regression.[Pubmed:12207237]
Anal Bioanal Chem. 2002 Sep;374(1):33-8.
A kinetic-spectrophotometric method for the determination of theophylline, Dyphylline and proxyphylline, based on their azo coupling reaction with the diazonium ion of sulfanilic acid after a treatment with alkali, is proposed. The absorbance is recorded from 340 to 600 nm every second during reaction for 90 s, and calibration is performed by partial least-squares regression, using first derivative spectra values. Mixtures containing 2.5-13 micro g mL(-1) Dyphylline and proxyphylline, and 2-9 micro g mL(-1) theophylline were successfully resolved with root mean squared errors of prediction (RMSEP) of 0.4, 0.3, and 0.2 for Dyphylline, proxyphylline, and theophylline, respectively. The proposed method was satisfactorily applied to the determination of the three compounds in a commercially available pharmaceutical preparation and provided results similar to those obtained by HPLC.
Dyphylline liposomes for delivery to the skin.[Pubmed:1545351]
J Pharm Sci. 1992 Feb;81(2):131-4.
Delivery of Dyphylline to the skin using liposomes was investigated. Xanthines are inhibitors of cAMP phosphodiesterase and have been considered for treatment of psoriasis. Dyphylline was chosen because of its solubility in water, which should allow for incorporation of higher concentrations within the liposomes. Liposomes containing Dyphylline were prepared by a method using sonication. Transmission electron micrography (TEM) visualization showed small particles ranging from 40 to 100 nm, and particle size distribution determined by light scattering showed the vesicles to have an average diameter of 360 nm. The transdermal delivery of free Dyphylline and Dyphylline incorporated in unilamellar liposomes was measured from polyethylene glycol (PEG), Carbopol gel, a PEG enhancer base, and water. For comparison, similar experiments were carried out with theophylline as well. When the drugs were incorporated in Carbopol gel, a large difference was seen between their fluxes, with free Dyphylline having the highest permeation, followed by liposomal Dyphylline, and then theophylline. With the PEG enhancer base, a very high permeation of theophylline was observed relative to Dyphylline and liposomal Dyphylline. From the PEG base, liposomal Dyphylline exhibited the lowest skin permeation flux relative to other bases. Using the PEG base for Dyphylline incorporated in liposomes, a high skin partitioning of the drug, along with low transdermal permeation, was measured. These results may indicate that the drug is localized in the skin.
